Research Papers

Tissue phantom for optical diagnostics based on a suspension of microspheres with a fractal size distribution

[+] Author Affiliations
D. Passos

Universidade do Algarve, Faculdade de Ciências e Tecnologia, Departamento de Física, Campus de Gambelas, 8000-139 Faro, Portugal

J. C. Hebden

University College London, Department of Medical Physics and Bioengineering, London WC1E 6BT, United Kingdom

P. N. Pinto, R. Guerra

Universidade do Algarve, Faculdade de Ciências e Tecnologia, Departamento de Física and Centro de Electrónica, Optoelectrónica e Telecomunicações (CEOT), Campus de Gambelas, 8000-139 Faro, Portugal

J. Biomed. Opt. 10(6), 064036 (December 08, 2005). doi:10.1117/1.2139971
History: Received February 24, 2005; Revised June 24, 2005; Accepted July 08, 2005; Published December 08, 2005
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We demonstrate experimentally the possibility of reproducing the phase function, absorption, and scattering coefficients of a real biological tissue (adult brain white matter and liver) using a suspension of polystyrene microspheres with a fractal size distribution. The design of a light scattering goniometer with a cylindrical cell in air is discussed, and phase function measurements using the device are described. The scattering coefficient is measured using transmission spectrophotometry and the absorption and reduced scattering coefficients are measured using a time-resolved method. A good match between real tissue and phantom parameters is demonstrated.

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© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

D. Passos ; J. C. Hebden ; P. N. Pinto and R. Guerra
"Tissue phantom for optical diagnostics based on a suspension of microspheres with a fractal size distribution", J. Biomed. Opt. 10(6), 064036 (December 08, 2005). ; http://dx.doi.org/10.1117/1.2139971


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