Research Papers

Effect of size of TiO2 nanoparticles embedded into stratum corneum on ultraviolet-A and ultraviolet-B sun-blocking properties of the skin

[+] Author Affiliations
Alexey P. Popov

M. V. Lomonosov Moscow State University, Physics Department and International Laser Center, Vorobiovy Gory, Moscow, 119992 Russia and University of Oulu and Infotech Oulu, Optoelectronics and Measurement Techniques Laboratory, 90014 Finland

Jürgen Lademann

Humboldt University, Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Medical Faculty Charité, Invalidenstr 110, Berlin, 10115 Germany

Alexander V. Priezzhev

M. V. Lomonosov Moscow State University, Physics Department and International Laser Center, Vorobiovy Gory, Moscow, 119992 Russia

Risto Myllylä

University of Oulu and Infotech Oulu, Optoelectronics and Measurement Techniques Laboratory, 90014 Finland

J. Biomed. Opt. 10(6), 064037 (December 08, 2005). doi:10.1117/1.2138017
History: Received September 14, 2004; Revised July 11, 2005; Accepted July 29, 2005; Published December 08, 2005
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Recently there has been a strong demand to protect human skin against negative effects of the UV solar light. This problem is interesting due to the increased frequency of human diseases caused by such radiation. We aim to evaluate how the optical properties of the horny layer of skin can be effectively changed by imbedding TiO2 fine particles to achieve the maximal attenuation of the UV solar radiation. In-depth distribution of TiO2 particles embedded into the skin by multiple administration of sunscreens is determined experimentally using the tape-stripping technique. A computer code implementing the Monte Carlo method is developed to simulate photon migration within the 20μm-thick horny layer filled with nanosized TiO2 spheres, 25to200nm in diameter. Dependencies of the UV radiation of two wavelengths (310 and 400nm) absorbed by and totally reflected from, as well as transmitted through the horny layer on the size of TiO2 particles are obtained and analyzed. The most attenuating particles are found to be 62 and 122nm in diameter for 310- and 400nm light, respectively. The former could be suggested as the main fraction to be used in sunscreens to prevent erythema.

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© 2005 Society of Photo-Optical Instrumentation Engineers

Citation

Alexey P. Popov ; Jürgen Lademann ; Alexander V. Priezzhev and Risto Myllylä
"Effect of size of TiO2 nanoparticles embedded into stratum corneum on ultraviolet-A and ultraviolet-B sun-blocking properties of the skin", J. Biomed. Opt. 10(6), 064037 (December 08, 2005). ; http://dx.doi.org/10.1117/1.2138017


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