0
Research Papers

Molecular interactions of exogenous chemical agents with collagen—implications for tissue optical clearing

[+] Author Affiliations
Alvin T. Yeh, Jason Hirshburg

Texas A&M University, Department of Biomedical Engineering, 337 Zachry Engineering Center, 3120 TAMU, College Station, Texas 77843

J. Biomed. Opt. 11(1), 014003 (January 24, 2006). doi:10.1117/1.2166381
History: Received June 20, 2005; Revised October 20, 2005; Accepted October 28, 2005; Published January 24, 2006
Text Size: A A A

Reduction of optical scattering in turbid biological tissues using nonreactive chemical agents has potential applications for light-based diagnostics and therapeutics. Optical clearing effects by exogenous chemical agents, in particular sugars and sugar alcohols, have been found to be temporary with tissue rehydration. Applications with dermatologic laser therapies are now being investigated, but suffer from the inability of studied agents to penetrate the superficial layers of human skin. Selection, design, and refinement of topically effective chemical agents are hindered by a lack of fundamental understanding of tissue clearing mechanisms. We present recent work, particularly from the biochemistry community, detailing molecular interactions between chemical agents and collagen. This body of work demonstrates the perturbative effects of sugars and sugar alcohols on collagen high-order structures at micro- and nanometer length scales by screening noncovalent bonding forces. In addition, these studies emphasize the nonreactive nature of agent-collagen interactions and the ability of noncovalent bonding forces to recover with agent removal and drive reassembly of destabilized collagen structures. A mechanism of tissue optical clearing is proposed based on agent destabilization of high-order collagen structures.

Figures in this Article
© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Alvin T. Yeh and Jason Hirshburg
"Molecular interactions of exogenous chemical agents with collagen—implications for tissue optical clearing", J. Biomed. Opt. 11(1), 014003 (January 24, 2006). ; http://dx.doi.org/10.1117/1.2166381


Access This Article
Sign In to Access Full Content
Please Wait... Processing your request... Please Wait.
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
 
Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content

Tables

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement


Buy this article ($18 for members, $25 for non-members).
Sign In