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Research Papers

Remineralization of in vitro dental caries assessed with polarization-sensitive optical coherence tomography

[+] Author Affiliations
Robert S. Jones, Cynthia L. Darling, John D. B. Featherstone, Daniel Fried

University of California, Department of Preventive and Restorative Dental Sciences, San Francisco, California 94143

J. Biomed. Opt. 11(1), 014016 (January 24, 2006). doi:10.1117/1.2161192
History: Received May 06, 2005; Revised August 22, 2005; Accepted August 30, 2005; Published January 24, 2006
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Polarization-sensitive optical coherence tomography (PS-OCT) is potentially useful for imaging the nonsurgical remineralization of dental enamel. This study uses an all-fiber-based PS-OCT system operating at 1310nm to image demineralized and fluoride-enhanced remineralized artificial lesions. PS-OCT images of lesions before and after remineralization are compared with the relative mineral loss ΔZ(%vol×μm), obtained from high resolution digital microradiography (DM), and chemical composition changes by infrared spectroscopy. Severe early artificial caries show a significant increase in perpendicular-axis integrated reflectivity after remineralization. After sectioning the samples, DM demonstrates that the lesions remineralized with new mineral and the lesion surface zone show significant restoration of mineral volume. PS-OCT and DM both do not show a major change in lesion depth. For less severe artificial caries, the perpendicular-axis image resolves the scattering and depolarization of an outer growth layer after remineralization. This outer layer has a mineral volume close to that of sound enamel, and spectroscopic analysis indicates that the layer is a highly crystalline phase of apatite, without carbonate substitutions that increase the solubility of sound enamel. This study determines that PS-OCT can image the effects of fluoride-enhanced remineralization of mild and severe early artificial in vitro caries.

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Robert S. Jones ; Cynthia L. Darling ; John D. B. Featherstone and Daniel Fried
"Remineralization of in vitro dental caries assessed with polarization-sensitive optical coherence tomography", J. Biomed. Opt. 11(1), 014016 (January 24, 2006). ; http://dx.doi.org/10.1117/1.2161192


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