Research Papers

Diffuse reflectance spectra of the palpebral conjunctiva and its utility as a noninvasive indicator of total hemoglobin

[+] Author Affiliations
John W. McMurdy

Brown University, Division of Engineering, Box D, Providence, Rhode Island 02906

Gregory D. Jay

Rhode Island Hospital & Brown University, Department of Emergency Medicine and Division of Engineering, 1 Hoppin St., Providence, Rhode Island 02903

Selim Suner

Rhode Island Hospital, Department of Emergency Medicine, 1 Hoppin St., Providence, Rhode Island 02903

Flor M. Trespalacios

Rhode Island Hospital, Department of Emergency Medicine, 593 Eddy Street, Providence, Rhode Island 02903

Gregory P. Crawford

Brown University, Division of Engineering and Department of Physics, Box D, Providence, Rhode Island 02906

J. Biomed. Opt. 11(1), 014019 (January 31, 2006). doi:10.1117/1.2167967
History: Received June 09, 2005; Revised August 29, 2005; Accepted September 06, 2005; Published January 31, 2006
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The palpebral conjunctiva is an attractive location to qualitatively examine for the presence of anemia; however, this method of diagnosis has not been shown to be accurate. A spectroscopic examination of the palpebral conjunctiva enables the use of a quantitative parameter as a basis for diagnoses. Visible range diffuse reflectance spectra from the palpebral conjunctiva are examined from 30 patients and hemoglobin levels are extracted from these signatures using both a partial least-squares (PLS) multivariate regression model and a discrete spectral region model. Hemoglobin concentration derived from both these models is compared to an in vitro measurement of hemoglobin. Root mean squared errors of cross validation for the two analytical methods are 0.67gdL and 1.07gdL, respectively. Conjunctival reflectance spectra coupled with a PLS analysis achieve an enhanced specificity and sensitivity for anemia diagnoses over reported observational studies using the palpebral conjunctiva and achieve improved accuracy to other reported methods of noninvasive hemoglobin measurement.

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

John W. McMurdy ; Gregory D. Jay ; Selim Suner ; Flor M. Trespalacios and Gregory P. Crawford
"Diffuse reflectance spectra of the palpebral conjunctiva and its utility as a noninvasive indicator of total hemoglobin", J. Biomed. Opt. 11(1), 014019 (January 31, 2006). ; http://dx.doi.org/10.1117/1.2167967


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