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Research Papers

Design and implementation of a multifrequency near-infrared diffuse optical tomography system

[+] Author Affiliations
Gultekin Gulsen, Bin Xiong, Ozlem Birgul, Orhan Nalcioglu

University of California, Tu and Yuen Center for Functional Onco-Imaging, Irvine, California 92697

J. Biomed. Opt. 11(1), 014020 (January 24, 2006). doi:10.1117/1.2161199
History: Received April 04, 2005; Revised July 26, 2005; Accepted August 29, 2005; Published January 24, 2006
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The design and implementation of a multifrequency and multispectral diffuse optical tomography system is described. Four wavelengths are utilized: 665, 785, 808, and 830nm. The system is based on a network analyzer, which provides rf modulation signals for the laser diodes, as well as measures the amplitude and the phase of the detected signals. Six different modulation frequencies ranging from 110to280MHz are used. The details of instrumentation, calibration, data acquisition, and performance of the system are given. A finite element algorithm is used to solve the diffusion equation, and an inverse solver based on this forward solver is implemented to calculate the absorption and scattering maps from the acquired data. Data acquisition for one wavelength is completed in less than 2.5min for a single modulation frequency. The measurement repeatability is 0.5% in ac intensity and 0.2deg in phase. The performance of the system is evaluated with phantom studies. A multifrequency reconstruction algorithm is used, in which a single absorption and scattering image pair is obtained using the whole dataset obtained at different modulation frequencies. It is shown that the multifrequency reconstruction approach provides superior image quality compared to the single frequency counterpart.

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Gultekin Gulsen ; Bin Xiong ; Ozlem Birgul and Orhan Nalcioglu
"Design and implementation of a multifrequency near-infrared diffuse optical tomography system", J. Biomed. Opt. 11(1), 014020 (January 24, 2006). ; http://dx.doi.org/10.1117/1.2161199


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