0
Review Papers

Image analysis methods for diffuse optical tomography

[+] Author Affiliations
Brian W. Pogue, Scott C. Davis, Xiaomei Song, Ben A. Brooksby, Hamid Dehghani, Keith D. Paulsen

Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755

J. Biomed. Opt. 11(3), 033001 (November 05, 2005January 06, 2006January 10, 2006June 20, 2006). doi:10.1117/1.2209908
History: Received November 05, 2005; Revised January 06, 2006; Accepted January 10, 2006; Published June 20, 2006
Text Size: A A A

Three major analytical tools in imaging science are summarized and demonstrated relative to optical imaging in vivo. Standard resolution testing is optimal when infinite contrast is used and hardware evaluation is the goal. However, deep tissue imaging of absorption or fluorescent contrast agents in vivo often presents a different problem, which requires contrast-detail analysis. This analysis shows that the minimum detectable sizes are in the range of 1/10 the outer diameter, whereas minimum detectable contrast values are in the range of 10 to 20% relative to the continuous background values. This is estimated for objects being in the center of the domain being imaged, and as the heterogeneous region becomes closer to the surface, the lower limit on size and contrast can become arbitrarily low and more dictated by hardware specifications. Finally, if human observer detection of abnormalities in the images is the goal, as is standard in most radiological practice, receiver operating characteristic (ROC) curve and location receiver operating characteristic curve (LROC) are used. Each of these three major areas of image interpretation and analysis are reviewed in the context of medical imaging as well as how they are used to quantify the performance of diffuse optical imaging of tissue.

Figures in this Article
© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Brian W. Pogue ; Scott C. Davis ; Xiaomei Song ; Ben A. Brooksby ; Hamid Dehghani, et al.
"Image analysis methods for diffuse optical tomography", J. Biomed. Opt. 11(3), 033001 (November 05, 2005January 06, 2006January 10, 2006June 20, 2006). ; http://dx.doi.org/10.1117/1.2209908


Access This Article
Sign In to Access Full Content
Please Wait... Processing your request... Please Wait.
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
 
Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content

Tables

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement

Buy this article ($18 for members, $25 for non-members).
Sign In