Research Papers

Two-photon absorption-controlled multidose drug release: a novel approach for secondary cataract treatment

[+] Author Affiliations
Hee-Cheol Kim, Sebastian Härtner

University of Marburg, Faculty of Chemistry, Hans-Meerwein-Str., Building H, D-35032 Marburg, Germany

Martin Behe, Thomas M. Behr

University of Marburg, Department of Nuclear Medicine, Baldingerstrasse, D-35033 Marburg, Germany

Norbert A. Hampp

University of Marburg, Faculty of Chemistry, Hans-Meerwein-Str., Building H, D-35032 Marburg, Germany and University of Marburg, Materials Science Center, D-35032 Marburg, Germany

J. Biomed. Opt. 11(3), 034024 (June 07, 2006). doi:10.1117/1.2209564
History: Received August 30, 2005; Revised March 20, 2006; Accepted March 21, 2006; Published June 07, 2006
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Tens of millions of cataract surgeries are done every year and the number is increasing heavily. Posterior capsule opacification is the major postoperative complication with an incidence of 10 to 50% within 5years, depending on the age of the patient. We present a novel approach for secondary cataract treatment in a noninvasive manner. Photochemically triggered drug release from a polymer enables repeated drug applications for cataract treatment years after implantation of the intraocular lens, just when needed. However, light in the visible spectral range must pass through the lens but must not induce drug release. We demonstrate that two-photon absorption photochemistry is a powerful tool to overcome this problem. With wavelengths in the visible regime, a photochemical reaction that requires energies in the UV is triggered. The high intensities needed for this process never occur in any lighting condition in daily lives, but may be easily obtained with focused laser beams routinely used in ophthalmology. The properties of the therapeutic system are specified and the function is demonstrated by in-vitro cell tests. Noninvasive multidose photochemically triggered drug release from implanted intraocular lenses carrying a drug depot may be a therapeutic as well as an economic choice to established treatments of secondary cataracts.

Figures in this Article
© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Hee-Cheol Kim ; Sebastian Härtner ; Martin Behe ; Thomas M. Behr and Norbert A. Hampp
"Two-photon absorption-controlled multidose drug release: a novel approach for secondary cataract treatment", J. Biomed. Opt. 11(3), 034024 (June 07, 2006). ; http://dx.doi.org/10.1117/1.2209564


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