Research Papers

Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy

[+] Author Affiliations
Jung-Taek Oh, Meng-Lin Li, Hao F. Zhang, Konstantin Maslov

Texas A&M University, Department of Biomedical Engineering, Optical Imaging Laboratory, 3120 TAMU, College Station, Texas 77843-3120

George Stoica

Texas A&M University, Department of Veterinary Pathobiology, 5547 TAMU, College Station, Texas 77843-5547

Lihong V. Wang

Texas A&M University, Department of Biomedical Engineering, Optical Imaging Laboratory, 3120 TAMU, College Station, Texas 77843-3120

J. Biomed. Opt. 11(3), 034032 (June 14, 2006). doi:10.1117/1.2210907
History: Received February 22, 2006; Revised April 17, 2006; Accepted April 17, 2006; Published June 14, 2006
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Dual-wavelength reflection-mode photoacoustic microscopy is used to noninvasively obtain three-dimensional (3-D) images of subcutaneous melanomas and their surrounding vasculature in nude mice in vivo. The absorption coefficients of blood and melanin-pigmented melanomas vary greatly relative to each other at these two optical wavelengths (764 and 584nm). Using high-resolution and high-contrast photoacoustic imaging in vivo with a near-infrared (764-nm) light source, the 3-D melanin distribution inside the skin is imaged, and the maximum thickness of the melanoma (0.5mm) is measured. The vascular system surrounding the melanoma is also imaged with visible light (584nm) and the tumor-feeding vessels found. This technique can potentially be used for melanoma diagnosis, prognosis, and treatment planning.

Figures in this Article
© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Jung-Taek Oh ; Meng-Lin Li ; Hao F. Zhang ; Konstantin Maslov ; George Stoica, et al.
"Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy", J. Biomed. Opt. 11(3), 034032 (June 14, 2006). ; http://dx.doi.org/10.1117/1.2210907


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