0
Special Section on Pioneers in Biomedical Optics: A.J. Welch

Angular measurements of light scattered by turbid chiral media using linear Stokes polarimeter

[+] Author Affiliations
Xinxin Guo, Michael F. G. Wood

Ontario Cancer Institute, Division of Biophysics and Bioimaging and University of Toronto, Department of Medical Biophysics, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada

I. Alex Vitkin

Ontario Cancer Institute, Division of Biophysics and Bioimaging and University of Toronto, Departments of Medical Biophysics and Radiation Oncology, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada

J. Biomed. Opt. 11(4), 041105 (September 01, 2006). doi:10.1117/1.2339134
History: Received August 22, 2005; Revised January 16, 2006; Accepted May 12, 2006; Published September 01, 2006; Online September 01, 2006
Text Size: A A A

The effects of turbid chiral media on light polarization are studied in different directions around the scattering samples using a refined linear Stokes polarimeter, which simplifies the signal analysis, and allows for the detailed investigations of scattered light. Because no moving parts are involved in a measurement at a specific detection direction, the determination accuracy of polarization states is increased. The results show that light depolarization increases with both turbidity and detection angle for low and moderately turbid samples; however, the angular dependence decreases with increasing turbidity. When the turbidity is increased to 100cm1, the depolarization becomes higher in the forward than in the backward direction. Polarization sensitive Monte Carlo simulations are used to verify some experimental observations. The results also demonstrate that surviving linear polarization fraction and overall intensity are more sensitive to the increase of glucose concentration in backward than in the forward direction in highly turbid media, indicating that backward geometry may be preferable for potential glucose detection in a biomedical context. Comparison measurements with optically inactive glycerol suggest that the refractive index matching effect, and not the chiral nature of the solute, dominates the observed optical rotation engendered by glucose in highly turbid media.

Figures in this Article
© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Xinxin Guo ; Michael F. G. Wood and I. Alex Vitkin
"Angular measurements of light scattered by turbid chiral media using linear Stokes polarimeter", J. Biomed. Opt. 11(4), 041105 (September 01, 2006). ; http://dx.doi.org/10.1117/1.2339134


Access This Article
Sign In to Access Full Content
Please Wait... Processing your request... Please Wait.
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
 
Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content

Tables

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement


Buy this article ($18 for members, $25 for non-members).
Sign In