Special Section on Pioneers in Biomedical Optics: A.J. Welch

Noninvasive optoacoustic online retinal temperature determination during continuous-wave laser irradiation

[+] Author Affiliations
Jochen Kandulla

Universität zu Lübeck, Institut für Biomedizinische Optik, Peter-Monnik-Weg 4, D-23562 Lübeck, Germany

Hanno Elsner

Universitätsklinikum Schleswig Holstein Campus Kiel, Klinik für Augenheilkunde, Hegewischstrass 2, 24105 Kiel, Germany

Reginald Birngruber, Ralf Brinkmann

Universität zu Lübeck, Institut für Biomedizinische Optik, Peter-Monnik-Weg 4, D-23562 Lübeck, Germany

J. Biomed. Opt. 11(4), 041111 (August 23, 2006). doi:10.1117/1.2236301
History: Received September 30, 2005; Revised January 23, 2006; Accepted January 23, 2006; Published August 23, 2006; Online August 23, 2006
Text Size: A A A

The therapeutic effect of most retinal laser treatments is initiated by a transient temperature increase. Although crucial to the effectiveness of the treatment, the temperature course is not exactly known due to individually different tissue properties. We develop an optoacoustic method to determine the retinal temperature increase in real time during continuous-wave (cw) laser irradiation, and perform temperature calculations to interpret the results exemplary for transpupillary thermotherapy (TTT). Porcine globes ex vivo and rabbit eyes in vivo are irradiated with a diode laser (λ=810nm, P3W, ϕ=2mm) for 60s. Simultaneously, pulses from a N2-laser pumped dye laser (λ=500nm, τ=3.5ns, E5μJ) are applied on the retina. Following its absorption, an ultrasonic pressure wave is emitted, which is detected by a transducer embedded in a contact lens. Using the previously measured temperature-dependent Grüneisen coefficient of chorioretinal tissue, a temperature raise in porcine eyes of 5.8°C(Wcm2) after 60s is observed and confirmed by simultaneous measurements with an inserted thermocouple. In a rabbit, we find 1.4°C(Wcm2) with, and 2.2°C(Wcm2) without perfusion at the same location. Coagulation of the rabbit’s retina occurs at ΔT=21°C after 40s. In conclusion, this optoacoustic method seems feasible for an in vivo real-time determination of temperature, opening the possibility for feedback control retinal laser treatments.

Figures in this Article
© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Jochen Kandulla ; Hanno Elsner ; Reginald Birngruber and Ralf Brinkmann
"Noninvasive optoacoustic online retinal temperature determination during continuous-wave laser irradiation", J. Biomed. Opt. 11(4), 041111 (August 23, 2006). ; http://dx.doi.org/10.1117/1.2236301


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement


  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.