Special Section on Pioneers in Biomedical Optics: A.J. Welch

Quantitative evaluation of optical coherence tomography signal enhancement with gold nanoshells

[+] Author Affiliations
Anant Agrawal

US Food and Drug Administration, Center for Devices and Radiological Health, Optical Diagnostics Laboratory, 12725 Twinbrook Parkway, HFZ-130, Rockville, Maryland 20852

Stanley Huang

Johns Hopkins University, Department of Biomedical Engineering, 318 Clark Hall, 3400 N. Charles Street, Baltimore, Maryland 21218

Alex Wei Haw Lin, Min-Ho Lee

Rice University, Department of Bioengineering, PO Box 1892, MS-142, Houston, Texas 77251-1892

Jennifer K. Barton

The University of Arizona, Division of Biomedical Engineering, 1230 E Speedway Boulevard, Tucson, Arizona 85721-0104

Rebekah A. Drezek

Rice University, Department of Bioengineering, PO Box 1892, MS-142, Houston, Texas 77251-1892

T. Joshua Pfefer

US Food and Drug Administration, Center for Devices and Radiological Health, Optical Diagnostics Laboratory, 12725 Twinbrook Parkway, HFZ-130, Rockville, Maryland 20852

J. Biomed. Opt. 11(4), 041121 (September 06, 2006). doi:10.1117/1.2339071
History: Received September 30, 2005; Revised February 24, 2006; Accepted April 11, 2006; Published September 06, 2006; Online September 06, 2006
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Nanoshell-enhanced optical coherence tomography (OCT) is a novel technique with the potential for molecular imaging and improved disease detection. However, optimization of this approach will require a quantitative understanding of the influence of nanoshell parameters on detected OCT signals. In this study, OCT was performed at 1310nm in water and turbid tissue-simulating phantoms to which nanoshells were added. The effect of nanoshell concentration, core diameter, and shell thickness on signal enhancement was characterized. Experimental results indicated trends that were consistent with predicted optical properties—a monotonic increase in signal intensity and attenuation with increasing shell and core size. Threshold concentrations for a 2-dB OCT signal intensity gain were determined for several nanoshell geometries. For the most highly backscattering nanoshells tested—291-nm core diameter, 25-nm shell thickness—a concentration of 109 nanoshells/mL was needed to produce this signal increase. Based on these results, we discuss various practical considerations for optimizing nanoshell-enhanced OCT. Quantitative experimental data presented here will facilitate optimization of OCT-based diagnostics and may also be relevant to other reflectance-based approaches as well.

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Anant Agrawal ; Stanley Huang ; Alex Wei Haw Lin ; Min-Ho Lee ; Jennifer K. Barton, et al.
"Quantitative evaluation of optical coherence tomography signal enhancement with gold nanoshells", J. Biomed. Opt. 11(4), 041121 (September 06, 2006). ; http://dx.doi.org/10.1117/1.2339071


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