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Special Section on Pioneers in Biomedical Optics: A.J. Welch

Quantification of the wound healing using polarization-sensitive optical coherence tomography

[+] Author Affiliations
Jung-Taek Oh

Institute for Medical Engineering, Wonju, Kangwon, Korea 220-842

Sang-Won Lee

Yonsei University, Biomedical Engineering Department, Wonju, Kangwon, Korea 220-710

Youn-Soo Kim, Ki-Beom Suhr

CnU Skin Clinic and CnU Skin Research Laboratory, Daejeon, Korea 301-712

Beop-Min Kim

Yonsei University, Biomedical Engineering Department, Wonju, Kangwon,, Korea 220-710

J. Biomed. Opt. 11(4), 041124 (September 30, 2005April 30, 2006May 22, 2006September 08, 2006September 08, 2006). doi:10.1117/1.2338826
History: Received September 30, 2005; Revised April 30, 2006; Accepted May 22, 2006; Published September 08, 2006; Online September 08, 2006
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We use polarization-sensitive optical coherence tomography (PS-OCT) to monitor the wound healing process in vitro and in vivo, which are affected by various drugs. Five rabbit subjects are used for in vitro studies and another five are used for in vivo studies. The in vitro studies are conducted to compare the PS-OCT images with histopathology. For each subject, three biopsy lesions are created on each ear: one site is not treated (control); the second site is treated with sphingosylphosphorylcholine, which is expected to promote healing; and the last is administered with tetraacetylphytosphingosine, which negatively affects the healing process. Each site is examined with a PS-OCT system at 1, 4, 7, 10, and 14- days after wound generation. The variations of phase retardation values caused by the collagen morphology changes on wound sites are quantified for all cases. Our results suggest that PS-OCT may be a useful tool for visualization of collagen fiber regeneration and for quantification of various drug effects during the wound healing process.

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Jung-Taek Oh ; Sang-Won Lee ; Youn-Soo Kim ; Beop-Min Kim and Ki-Beom Suhr
"Quantification of the wound healing using polarization-sensitive optical coherence tomography", J. Biomed. Opt. 11(4), 041124 (September 30, 2005April 30, 2006May 22, 2006September 08, 2006September 08, 2006). ; http://dx.doi.org/10.1117/1.2338826


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