Special Section on Pioneers in Biomedical Optics: A.J. Welch

Quantification of the wound healing using polarization-sensitive optical coherence tomography

[+] Author Affiliations
Jung-Taek Oh

Institute for Medical Engineering, Wonju, Kangwon, Korea 220-842

Sang-Won Lee

Yonsei University, Biomedical Engineering Department, Wonju, Kangwon, Korea 220-710

Youn-Soo Kim, Ki-Beom Suhr

CnU Skin Clinic and CnU Skin Research Laboratory, Daejeon, Korea 301-712

Beop-Min Kim

Yonsei University, Biomedical Engineering Department, Wonju, Kangwon,, Korea 220-710

J. Biomed. Opt. 11(4), 041124 (September 08, 2006). doi:10.1117/1.2338826
History: Received September 30, 2005; Revised April 30, 2006; Accepted May 22, 2006; Published September 08, 2006; Online September 08, 2006
Text Size: A A A

We use polarization-sensitive optical coherence tomography (PS-OCT) to monitor the wound healing process in vitro and in vivo, which are affected by various drugs. Five rabbit subjects are used for in vitro studies and another five are used for in vivo studies. The in vitro studies are conducted to compare the PS-OCT images with histopathology. For each subject, three biopsy lesions are created on each ear: one site is not treated (control); the second site is treated with sphingosylphosphorylcholine, which is expected to promote healing; and the last is administered with tetraacetylphytosphingosine, which negatively affects the healing process. Each site is examined with a PS-OCT system at 1, 4, 7, 10, and 14- days after wound generation. The variations of phase retardation values caused by the collagen morphology changes on wound sites are quantified for all cases. Our results suggest that PS-OCT may be a useful tool for visualization of collagen fiber regeneration and for quantification of various drug effects during the wound healing process.

Figures in this Article
© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Jung-Taek Oh ; Sang-Won Lee ; Youn-Soo Kim ; Ki-Beom Suhr and Beop-Min Kim
"Quantification of the wound healing using polarization-sensitive optical coherence tomography", J. Biomed. Opt. 11(4), 041124 (September 08, 2006). ; http://dx.doi.org/10.1117/1.2338826


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement


  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.