Special Section on Pioneers in Biomedical Optics: A.J. Welch

Low-coherence enhanced backscattering: review of principles and applications for colon cancer screening

[+] Author Affiliations
Young L. Kim, Vladimir M. Turzhitsky, Yang Liu

Northwestern University,Biomedical Engineering Department, Evanston, Illinois 60208

Hemant K. Roy, Ramesh K. Wali

Evanston-Northwestern Healthcare,Department of Medicine, Evanston, Illinois 60201

Hariharan Subramanian, Prabhakar Pradhan

Northwestern University,Biomedical Engineering Department, Evanston, Illinois 60208

Vadim Backman

Northwestern University,Biomedical Engineering Department, Evanston, Illinois 60208 and, Evanston-Northwestern Healthcare,Department of Medicine, Evanston, Illinois 60201

J. Biomed. Opt. 11(4), 041125 (July 24, 2006). doi:10.1117/1.2236292
History: Received September 22, 2005; Revised December 01, 2005; Accepted January 06, 2006; Published July 24, 2006; Online July 24, 2006
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The phenomenon of enhanced backscattering (EBS) of light, also known as coherent backscattering (CBS) of light, has been the object of intensive investigation in nonbiological media over the last two decades. However, there have been only a few attempts to explore EBS for tissue characterization and diagnosis. We have recently made progress in the EBS measurements in tissue by taking advantage of low spatial coherence illumination, which has led us to the development of low-coherence enhanced backscattering (LEBS) spectroscopy. In this work, we review the current state of research on LEBS. After a brief discussion of the basic principle of EBS and LEBS, we present an overview of the unique features of LEBS for tissue characterization, and show that LEBS enables depth-selective spectroscopic assessment of mucosal tissue. Then, we demonstrate the potential of LEBS spectroscopy for predicting the risk of colon carcinogenesis and colonoscopy-free screening for colorectal cancer (CRC).

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Young L. Kim ; Vladimir M. Turzhitsky ; Yang Liu ; Hemant K. Roy ; Ramesh K. Wali, et al.
"Low-coherence enhanced backscattering: review of principles and applications for colon cancer screening", J. Biomed. Opt. 11(4), 041125 (July 24, 2006). ; http://dx.doi.org/10.1117/1.2236292


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