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Research Papers

Time-gated optical system for depth-resolved functional brain imaging

[+] Author Affiliations
Juliette Selb, Danny K. Joseph, David A. Boas

Massachusetts General Hospital, Athinoula A. Martinos Center, Photon Migration Imaging Laboratory, Building 149, 13th Street, Charlestown, Massachusetts 02129

J. Biomed. Opt. 11(4), 044008 (August 31, 2006). doi:10.1117/1.2337320
History: Received December 06, 2005; Revised April 10, 2006; Accepted April 26, 2006; Published August 31, 2006; Online August 31, 2006
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We present a time-domain optical system for functional imaging of the adult head. We first describe the instrument, which is based on a Ti:Sapphire pulsed laser (wavelength 750–850nm) and an intensified CCD camera enabling parallel detection of multiple fibers. We characterize the system in terms of sensitivity and signal-to-noise ratio, instrument response function, cross-talk, stability, and reproducibility. We then describe two applications of the instrument: the characterization of baseline optical properties of homogeneous scattering media, and functional brain imaging. For the second application, we developed a two-part probe consisting in two squares of 4×4 sources and 3×3 detectors. The laser source is time-multiplexed to define 4 states of 8 sources that can be turned on during the same camera frame while minimizing cross-talk. On the detection side, we use for each detector 7 fibers of different lengths creating an optical delay, and enabling simultaneous detection in 7 windows (by steps of 500ps) for each detector. This multiple window detection allows depth sensitivity. The imaging probe was tested on dynamic phantoms and a preliminary result on an adult performing a motor task shows discrimination between superficial and cortical responses to the stimulus on both hemispheres.

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Juliette Selb ; Danny K. Joseph and David A. Boas
"Time-gated optical system for depth-resolved functional brain imaging", J. Biomed. Opt. 11(4), 044008 (August 31, 2006). ; http://dx.doi.org/10.1117/1.2337320


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