Research Papers

Diffuse optical tomographic reconstruction using multifrequency data

[+] Author Affiliations
Mehmet Burcin Unlu, Ozlem Birgul, Roshanak Shafiiha, Gultekin Gulsen, Orhan Nalcioglu

University of California Tu and Yuen Center for Functional Onco-Imaging Irvine, California 92697

J. Biomed. Opt. 11(5), 054008 (October 20, 2006). doi:10.1117/1.2363370
History: Received October 01, 2005; Revised April 05, 2006; Accepted May 10, 2006; Published October 20, 2006; Online October 20, 2006
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We investigated the use of multifrequency diffuse optical tomography (MF-DOT) data for the reconstruction of the optical parameters. The experiments were performed in a 63mm diameter cylindrical phantom containing a 15mm diameter cylindrical object. Modulation frequencies ranging from 110MHz to 280MHz were used in the phantom experiments changing the contrast in absorption of the object with respect to the phantom while keeping the scattering value the same. The diffusion equation was solved using the finite element method. The sensitivity information from each frequency was combined to form a single Jacobian. The inverse problem was solved iteratively by minimizing the difference between the measurements and forward problem using single and multiple modulation frequency data. A multiparameter Tikhonov scheme was used for regularization. The phantom results show that the peak absorption coefficient in a region of interest was obtained with an error less then 5% using two-frequency reconstruction for absorption contrast values up to 2.2 times higher than background and 10% for the absorption contrast values larger than 2.2. The use of two-frequency data is sufficient to improve the quantitative accuracy compared with the single frequency reconstruction with appropriate selection of these frequencies.

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© 2006 Society of Photo-Optical Instrumentation Engineers


Mehmet Burcin Unlu ; Ozlem Birgul ; Roshanak Shafiiha ; Gultekin Gulsen and Orhan Nalcioglu
"Diffuse optical tomographic reconstruction using multifrequency data", J. Biomed. Opt. 11(5), 054008 (October 20, 2006). ; http://dx.doi.org/10.1117/1.2363370

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