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Research Papers

Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser

[+] Author Affiliations
Long-Sheng Lu

National Taiwan UniversityGraduate Institute of Pharmacology Taipei, Taiwan

Chih-Wei Lu, I-Jen Hsu, Meng-Tsan Tsai, C. C. Yang, Yean-Woei Kiang

National Taiwan UniversityGraduate Institute of Electro-Optical Engineering and Department of Electrical Engineering No. 1, Section 4, Roosevelt Road Taipei, Taiwan

Chia-Wei Sun, Yih-Ming Wang

National Taiwan University,Graduate Institute of Electro-Optical Engineering, Taipei, Taiwan

Chau-Chung Wu

National Taiwan UniversityDepartment of Primary Care Medicine and Department of Internal Medicine Taipei, Taiwan

J. Biomed. Opt. 11(5), 054016 (January 05, 2004May 12, 2005February 15, 2006May 23, 2006October 20, 2006October 20, 2006). doi:10.1117/1.2363358
History: Received January 05, 2004; Revised May 12, 2005; Revised February 15, 2006; Accepted May 23, 2006; Published October 20, 2006; Online October 20, 2006
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A polarization-sensitive optical coherence tomography (PSOCT) system using a femtosecond-laser as the broadband light source is implemented with the axial resolution of 5μm in free space. Through the design of path-length difference between the two polarization inputs and the modulation of one of the polarization inputs, the PSOCT images of various input and output polarization combinations can be distinguished and simultaneously collected. The PSOCT system is then used for in vitro scanning of the myocardium tissues of normal and infarcted rat hearts. The destruction of the birefringence nature of the fiber muscle in the infarcted heart can be clearly observed.

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Long-Sheng Lu ; Chih-Wei Lu ; Chia-Wei Sun ; Chau-Chung Wu ; Yih-Ming Wang, et al.
"Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser", J. Biomed. Opt. 11(5), 054016 (January 05, 2004May 12, 2005February 15, 2006May 23, 2006October 20, 2006October 20, 2006). ; http://dx.doi.org/10.1117/1.2363358


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