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Research Papers

Pulse glucometry: a new approach for noninvasive blood glucose measurement using instantaneous differential near-infrared spectrophotometry

[+] Author Affiliations
K. Yamakoshi

Kanazawa University, Graduate School of Natural Science and Technology, Kanazawa 920-1192, Japan

Y. Yamakoshi

TYT Institute of Technology Corp., Kanazawa, Japan

J. Biomed. Opt. 11(5), 054028 (October 24, 2006). doi:10.1117/1.2360919
History: Received November 17, 2005; Revised April 17, 2006; Accepted June 22, 2006; Published October 24, 2006; Online October 24, 2006
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We describe a new optical method for noninvasive blood glucose (BGL) measurement. Optical methods are confounded by basal optical properties of tissues, especially water and other biochemical species, and by the very small glucose signal. We address these problems by using fast spectrophotometric analysis in a finger, deriving 100 transmittance spectra per second, to resolve optical spectra (900to1700nm) of blood volume pulsations throughout the cardiac cycle. Difference spectra are calculated from the pulsatile signals, thereby eliminating the effects of bone, other tissues, and nonpulsatile blood. A partial least squares (PLS) model is used with the measured spectral data to predict BGL levels. Using glucose tolerance tests in 27 healthy volunteers, periodic optical measurements were made simultaneously with collection of blood samples for in vitro glucose analysis. Altogether, 603 paired data sets were obtained in all subjects and two-thirds of the data or of the subjects randomly selected were used for the PLS calibration model and the rest for the prediction. Bland-Altman and error-grid analyses of the predicted and measured BGL levels indicated clinically acceptable accuracy. We conclude that the new method, named pulse glucometry, has adequate performance for safe, noninvasive estimation of BGL.

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

K. Yamakoshi and Y. Yamakoshi
"Pulse glucometry: a new approach for noninvasive blood glucose measurement using instantaneous differential near-infrared spectrophotometry", J. Biomed. Opt. 11(5), 054028 (October 24, 2006). ; http://dx.doi.org/10.1117/1.2360919


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