Research Papers

Imaging acute thermal burns by photoacoustic microscopy

[+] Author Affiliations
Hao F. Zhang, Konstantin Maslov

Texas A&M University, Department of Biomedical Engineering, Optical Imaging Laboratory, 3120 TAMU, College Station, Texas 77843-3120

George Stoica

Texas A&M University, Department of Veterinary Pathobiology, College Station, Texas 77843-5547

Lihong V. Wang

Texas A&M University, Department of Biomedical Engineering, Optical Imaging Laboratory, 3120 TAMU, College Station, Texas 77843-3120

J. Biomed. Opt. 11(5), 054033 (September 21, 2006). doi:10.1117/1.2355667
History: Received May 18, 2006; Revised July 17, 2006; Accepted July 19, 2006; Published September 21, 2006; Online September 21, 2006
Text Size: A A A

The clinical significance of a burn depends on the percentage of total body involved and the depth of the burn. Hence a noninvasive method that is able to evaluate burn depth would be of great help in clinical evaluation. To this end, photoacoustic microscopy is used to determine the depth of acute thermal burns by imaging the total hemoglobin concentration in the blood that accumulates along the boundaries of injuries as a result of thermal damage to the vasculature. We induce acute thermal burns in vivo on pig skin with cautery. Photoacoustic images of the burns are acquired after skin excision. In a burn treated at 175°C for 20s, the maximum imaged burn depth is 1.73±0.07mm. In burns treated at 150°C for 5, 10, 20, and 30s, respectively, the trend of increasing maximum burn depth with longer thermal exposure is demonstrated.

Figures in this Article
© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Hao F. Zhang ; Konstantin Maslov ; George Stoica and Lihong V. Wang
"Imaging acute thermal burns by photoacoustic microscopy", J. Biomed. Opt. 11(5), 054033 (September 21, 2006). ; http://dx.doi.org/10.1117/1.2355667


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement


  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.