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Research Papers

Imaging acute thermal burns by photoacoustic microscopy

[+] Author Affiliations
Hao F. Zhang, Konstantin Maslov

Texas A&M University, Department of Biomedical Engineering, Optical Imaging Laboratory, 3120 TAMU, College Station, Texas 77843-3120

George Stoica

Texas A&M University, Department of Veterinary Pathobiology, College Station, Texas 77843-5547

Lihong V. Wang

Texas A&M University, Department of Biomedical Engineering, Optical Imaging Laboratory, 3120 TAMU, College Station, Texas 77843-3120

J. Biomed. Opt. 11(5), 054033 (May 18, 2006July 17, 2006July 19, 2006September 21, 2006September 21, 2006). doi:10.1117/1.2355667
History: Received May 18, 2006; Revised July 17, 2006; Accepted July 19, 2006; Published September 21, 2006; Online September 21, 2006
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The clinical significance of a burn depends on the percentage of total body involved and the depth of the burn. Hence a noninvasive method that is able to evaluate burn depth would be of great help in clinical evaluation. To this end, photoacoustic microscopy is used to determine the depth of acute thermal burns by imaging the total hemoglobin concentration in the blood that accumulates along the boundaries of injuries as a result of thermal damage to the vasculature. We induce acute thermal burns in vivo on pig skin with cautery. Photoacoustic images of the burns are acquired after skin excision. In a burn treated at 175°C for 20s, the maximum imaged burn depth is 1.73±0.07mm. In burns treated at 150°C for 5, 10, 20, and 30s, respectively, the trend of increasing maximum burn depth with longer thermal exposure is demonstrated.

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Hao F. Zhang ; George Stoica ; Lihong V. Wang and Konstantin Maslov
"Imaging acute thermal burns by photoacoustic microscopy", J. Biomed. Opt. 11(5), 054033 (May 18, 2006July 17, 2006July 19, 2006September 21, 2006September 21, 2006). ; http://dx.doi.org/10.1117/1.2355667


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