Research Papers

Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements

[+] Author Affiliations
Stefan A. Carp, Tina Kauffman, Qianqian Fang

Harvard Medical School, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129

Elizabeth Rafferty, Richard Moore, Daniel Kopans

Harvard Medical School, Massachusetts General Hospital, Department of Radiology, Boston, Massachusetts 02114

David Boas

Harvard Medical School, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129

J. Biomed. Opt. 11(6), 064016 (December 18, 2006). doi:10.1117/1.2397572
History: Received April 18, 2006; Revised July 28, 2006; Accepted August 01, 2006; Published December 18, 2006; Online December 18, 2006
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We use optical spectroscopy to characterize the influence of mammographic-like compression on the physiology of the breast. We note a reduction in total hemoglobin content, tissue oxygen saturation, and optical scattering under compression. We also note a hyperemic effect during repeated compression cycles. By modeling the time course of the tissue oxygen saturation, we are able to obtain estimates for the volumetric blood flow (1.64±0.6mL100mLmin) and the oxygen consumption (1.97±0.6μmol100mLmin) of compressed breast tissue. These values are comparable to estimates obtained from previously published positron emission tomography (PET) measurements. We conclude that compression-induced changes in breast physiological properties are significant and should be accounted for when performing optical breast imaging. Additionally, the dynamic characteristics of the changes in breast physiological parameters, together with the ability to probe the tissue metabolic state, may prove useful for breast cancer detection.

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Stefan A. Carp ; Tina Kauffman ; Qianqian Fang ; Elizabeth Rafferty ; Richard Moore, et al.
"Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements", J. Biomed. Opt. 11(6), 064016 (December 18, 2006). ; http://dx.doi.org/10.1117/1.2397572


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