Research Papers

Time-resolved imaging of optical coefficients through murine chest cavities

[+] Author Affiliations
Mark J. Niedre, Gordon M. Turner, Vasilis Ntziachristos

Massachusetts General Hospital, Harvard Medical School, Laboratory for Bio-Optics and Molecular Imaging, Center for Molecular Imaging Research, Charlestown, Massachusetts 02129

J. Biomed. Opt. 11(6), 064017 (November 30, 2006). doi:10.1117/1.2400702
History: Received May 09, 2006; Revised July 17, 2006; Accepted August 01, 2006; Published November 30, 2006; Online November 30, 2006
Text Size: A A A

As small animal optical imaging and tomography are gaining popularity for interrogating functional and molecular events in vivo, it becomes increasingly necessary to gain knowledge of the optical properties of the species investigated to better understand and describe photon propagation through their tissues. To achieve characterization of the spatial variation of average optical properties through murine chest cavities, time- and spatially resolved measurements of femto-second laser pulse transmission are performed through mice using a high-speed gated image intensifier. Application of time-resolved diffusion theory for finite slab geometry is first confirmed on phantoms and then applied to in vivo measurements for spatially resolving and quantifying mouse optical properties. Photon transmission images through mouse chest cavities are further obtained at different time gates to visualize the spatial variation observed and confirm the optical coefficient patterns calculated.

Figures in this Article
© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Mark J. Niedre ; Gordon M. Turner and Vasilis Ntziachristos
"Time-resolved imaging of optical coefficients through murine chest cavities", J. Biomed. Opt. 11(6), 064017 (November 30, 2006). ; http://dx.doi.org/10.1117/1.2400702


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.