Research Papers

Improving performance of reflectance diffuse optical imaging using a multicentered mode

[+] Author Affiliations
Qing Zhao, Lijun Ji, Tianzi Jiang

Chinese Academy of Sciences, Institute of Automation, National Laboratory of Pattern Recognition, Beijing, China

J. Biomed. Opt. 11(6), 064019 (December 11, 2006). doi:10.1117/1.2400703
History: Received January 20, 2006; Revised July 12, 2006; Accepted July 18, 2006; Published December 11, 2006; Online December 11, 2006
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We propose a novel multicentered mode for arrangement of optical fibers to improve the imaging performance of reflectance diffuse optical imaging (rDOI). Simulations performed using a semi-infinite model show that the proposed multicentered geometries can achieve a maximum of 42 overlapping measurements. The contrast-to-noise ratio (CNR) analysis indicates that the best spatial resolution is 1mm in radius and the contrast resolution is less than 1.05 for the multicentered geometries. The results from simulations indicate significant improvement in image quality compared to the single-centered mode and previous geometries. Additional experimental results on a single human subject lead to the conclusion that the proposed multicentered geometries are appropriate for exploring activations in the human brain. From the results of this research, we conclude that the proposed multicentered mode could advance the performance of rDOI both in image quality and practical convenience.

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Qing Zhao ; Lijun Ji and Tianzi Jiang
"Improving performance of reflectance diffuse optical imaging using a multicentered mode", J. Biomed. Opt. 11(6), 064019 (December 11, 2006). ; http://dx.doi.org/10.1117/1.2400703


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