Research Papers

Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study

[+] Author Affiliations
Ulas Sunar

University of Pennsylvania, Department of Physics and Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104-6396

Harry Quon

University of Pennsylvania, Department of Radiation Oncology, Philadelphia, Pennsylvania 19104

Turgut Durduran

University of Pennsylvania, Department of Physics and Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104-6396

Jun Zhang, Juan Du

University of Pennsylvania, Department of Biochemistry and Biophysics, Philadelphia, Pennsylvania 19104

Chao Zhou, Guoqiang Yu, Regine Choe

University of Pennsylvania, Department of Physics and Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104-6396

Alex Kilger, Robert Lustig, Laurie Loevner

University of Pennsylvania, Department of Radiation Oncology, Philadelphia, Pennsylvania 19104

Shoko Nioka, Britton Chance

University of Pennsylvania, Department of Biochemistry and Biophysics, Philadelphia, Pennsylvania 19104

Arjun G. Yodh

University of Pennsylvania, Department of Physics and Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104-6396

J. Biomed. Opt. 11(6), 064021 (November 22, 2006). doi:10.1117/1.2397548
History: Received January 18, 2006; Revised July 20, 2006; Accepted July 21, 2006; Published November 22, 2006; Online November 22, 2006
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This pilot study explores the potential of noninvasive diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy (DRS) for monitoring early relative blood flow (rBF), tissue oxygen saturation (StO2), and total hemoglobin concentration (THC) responses to chemo-radiation therapy in patients with head and neck tumors. rBF, StO2, and THC in superficial neck tumor nodes of eight patients are measured before and during the chemo-radiation therapy period. The weekly rBF, StO2, and THC kinetics exhibit different patterns for different individuals, including significant early blood flow changes during the first two weeks. Averaged blood flow increases (52.7±9.7)% in the first week and decreases (42.4±7.0)% in the second week. Averaged StO2 increases from (62.9±3.4)% baseline value to (70.4±3.2)% at the end of the second week, and averaged THC exhibits a continuous decrease from pretreatment value of (80.7±7.0)[μM] to (73.3±8.3)[μM] at the end of the second week and to (63.0±8.1)[μM] at the end of the fourth week of therapy. These preliminary results suggest daily diffuse-optics-based therapy monitoring is feasible during the first two weeks and may have clinical promise.

Figures in this Article
© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Ulas Sunar ; Harry Quon ; Turgut Durduran ; Jun Zhang ; Juan Du, et al.
"Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study", J. Biomed. Opt. 11(6), 064021 (November 22, 2006). ; http://dx.doi.org/10.1117/1.2397548


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