Research Papers

Development and validation of a multiwavelength spatial domain near-infrared oximeter to detect cerebral hypoxia-ischemia

[+] Author Affiliations
Lindsey A. Nelson, John C. McCann, Andres W. Loepke, Jun Wu

Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Department of Anesthesia and Pediatrics, Institute of Pediatric Anesthesia, Cincinnati, Ohio 45229-3039

Baruch Ben Dor

Near Infrared Monitoring Incorporated, Philadelphia, Pennsylvania 19104

C. Dean Kurth

Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Department of Anesthesia and Pediatrics, Institute of Pediatric Anesthesia, Cincinnati, Ohio 45229-3039

J. Biomed. Opt. 11(6), 064022 (November 28, 2006). doi:10.1117/1.2393251
History: Received July 21, 2005; Revised July 12, 2006; Accepted July 14, 2006; Published November 28, 2006; Online November 28, 2006
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Detection of cerebral hypoxia-ischemia in infants remains problematic, as current monitors in clinical practice are impractical, insensitive, or nonspecific. Our study develops a multiwavelength spatial domain construct for near-infrared spectroscopy (NIRS) to detect cerebral hypoxia-ischemia and evaluates the construct in several models. The NIRS probe contains photodiode detectors 2, 3, and 4cm from a three-wavelength, light-emitting diode. A construct determines cerebral O2 saturation based on spatial domain principles. Device performance and construct validity are examined in in-vitro models simulating the brain, and in piglets subjected to hypoxia, hypoxia-ischemia, and hyperoxic conditions using a weighted average of arterial and cerebral venous O2 saturation measured by CO-oximetry. The results in the brain models verify key equations in the construct and demonstrate reliable performance of the device. In piglets, the device measures cerebral O2 saturation with bias ±4% and precision ±8%. In conclusion, this NIRS device accurately detects cerebral hypoxia-ischemia and is of a design that is practical for clinical application.

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Lindsey A. Nelson ; John C. McCann ; Andres W. Loepke ; Jun Wu ; Baruch Ben Dor, et al.
"Development and validation of a multiwavelength spatial domain near-infrared oximeter to detect cerebral hypoxia-ischemia", J. Biomed. Opt. 11(6), 064022 (November 28, 2006). ; http://dx.doi.org/10.1117/1.2393251


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