Research Papers

Spatially resolved reflectance spectroscopy for diagnosis of cervical precancer: Monte Carlo modeling and comparison to clinical measurements

[+] Author Affiliations
Dizem Arifler

Eastern Mediterranean University, Department of Physics, Famagusta, Cyprus

Calum MacAulay

The British Columbia Cancer Research Center, Department of Cancer Imaging, Vancouver, British Columbia, V5Z1L3, Canada

Michele Follen

The University of Texas M. D. Anderson Cancer Center, Department of Gynecologic Oncology and Center for Biomedical Engineering, Houston, Texas 77030

Rebecca Richards-Kortum

Rice University, Department of Bioengineering, Houston, Texas 77005

J. Biomed. Opt. 11(6), 064027 (November 20, 2006). doi:10.1117/1.2398932
History: Received February 27, 2006; Revised August 07, 2006; Accepted August 11, 2006; Published November 20, 2006; Online November 20, 2006
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We present Monte Carlo modeling studies to provide a quantitative understanding of contrast observed in spatially resolved reflectance spectra of normal and highly dysplastic cervical tissue. Simulations have been carried out to analyze the sensitivity of spectral measurements to a range of changes in epithelial and stromal optical properties that are reported to occur as dysplasia develops and to predict reflectance spectra of normal and highly dysplastic tissue at six different source-detector separations. Simulation results provide important insights into specific contributions of different optical parameters to the overall spectral response. Predictions from simulations agree well with in vivo measurements from cervical tissue and successfully describe spectral differences observed in reflectance measurements from normal and precancerous tissue sites. Penetration depth statistics of photons detected at the six source-detector separations are also presented to reveal the sampling depth profile of the fiber-optic probe geometry simulated. The modeling studies presented provide a framework to meaningfully interpret optical signals obtained from epithelial tissues and to optimize design of optical sensors for in vivo reflectance measurements for precancer detection. Results from this study can facilitate development of analytical photon propagation models that enable inverse estimation of diagnostically relevant optical parameters from in vivo reflectance measurements.

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Dizem Arifler ; Calum MacAulay ; Michele Follen and Rebecca Richards-Kortum
"Spatially resolved reflectance spectroscopy for diagnosis of cervical precancer: Monte Carlo modeling and comparison to clinical measurements", J. Biomed. Opt. 11(6), 064027 (November 20, 2006). ; http://dx.doi.org/10.1117/1.2398932


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