Research Papers

Cell membrane and gold nanoparticles effects on optical immersion experiments with noncancerous and cancerous cells: finite-difference time-domain modeling

[+] Author Affiliations
Stoyan Tanev

Carleton University, Department of Systems and Computer Engineering, Ottawa, Ontario, Canada

Valery V. Tuchin

Saratov State University, Institute of Optics and Biophotonics, Saratov, 410012 Russia

Paul Paddon

Lumerical Solutions, Inc., Vancouver, British Columbia, Canada

J. Biomed. Opt. 11(6), 064037 (December 13, 2006). doi:10.1117/1.2400239
History: Received May 17, 2006; Revised September 19, 2006; Accepted September 20, 2006; Published December 13, 2006; Online December 13, 2006
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Pilot results on the application of the finite-difference time-domain (FDTD) approach for studying the implementation of the optical immersion technique for the visualization of single and multiple gold nanoparticles in biological cells are presented. We focus on two different scenarios considering single biological cells containing (1) cytoplasm, nucleus, and membrane and (2) cytoplasm, nucleus, gold nanoparticles, and membrane. To the best of our knowledge, this is the first time the cell membrane thickness and gold nanoparticle effects on the forward scattered light from biological cells are discussed. The applicability and the potential of the FDTD approach for studying optical immersion technique enhanced bioimaging is demonstrated.

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

Stoyan Tanev ; Valery V. Tuchin and Paul Paddon
"Cell membrane and gold nanoparticles effects on optical immersion experiments with noncancerous and cancerous cells: finite-difference time-domain modeling", J. Biomed. Opt. 11(6), 064037 (December 13, 2006). ; http://dx.doi.org/10.1117/1.2400239


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