Special Section on Photonics in the Auditory System

In vivo imaging and low-coherence interferometry of organ of Corti vibration

[+] Author Affiliations
Fangyi Chen

Oregon Health and Science University, Oregon Hearing Research Center, 3181 Southwest Sam Jackson Park Road, NRC04, Portland, Oregon 97239-3098

Niloy Choudhury

Oregon Health and Science University, Biomedical Engineering, CH13B, 3303 Southwest Bond Avenue, Portland, Oregon 97239

Jiefu Zheng, Scott Matthews

Oregon Health and Science University, Oregon Hearing Research Center, 3181 Southwest Sam Jackson Park Road, NRC04, Portland, Oregon 97239-3098

Alfred L. Nutall

Oregon Health and Science University, Oregon Hearing Research Center, 3181 Southwest Sam Jackson Park Road, NRC04, Portland, Oregon 97239-3098 and Oregon Health and Science University, Biomedical Engineering, CH13B, 3303 Southwest Bond Avenue, Portland, Oregon 97239 and The University of Michigan, Kresge Hearing Research Institute, 1301 East Ann Street, Ann Arbor, Michigan 48109-0506 and Shanghai Jiao Tong University, Renji Hospital, Department of Otolaryngology, 1954 Shanghai Huansan Road, Shanghai, China

Steven L. Jacques

Oregon Health and Science University, Biomedical Engineering, CH13B, 3303 Southwest Bond Avenue, Portland, Oregon 97239 and Oregon Health and Science University, Dermatology, CH13B, 3303 Southwest Bond Avenue, Portland, Oregon 97239

J. Biomed. Opt. 12(2), 021006 (April 12, 2007). doi:10.1117/1.2717134
History: Received June 23, 2006; Revised December 28, 2006; Accepted January 15, 2007; Published April 12, 2007
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An optical coherence tomography (OCT) system is built to acquire in vivo both images and vibration measurements of the organ of Corti of the guinea pig. The organ of Corti is viewed through a 300-μm-diam hole in the bony wall of the cochlea at the scala tympani of the first cochlear turn. In imaging mode, the image is acquired as reflectance R(x,z). In vibration mode, the basilar membrane (BM) or reticular lamina (RL) are selected by the investigator interactively from the R(x,z) image. Under software control, the system moves the scanning mirrors to bring the sensing volume of the measurement to the desired membrane location. In vivo images of the organ of Corti are presented, indicating reflectance signals from the BM, RL, tectorial membrane, and Reissner’s membrane. The tunnel of Corti and the inner sulcus are also visible in the images. Vibrations of ±2 and ±22nm are recorded in the BM in response to low and high sound levels at 14kHz above a noise floor of 0.2nm.

Figures in this Article
© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Fangyi Chen ; Niloy Choudhury ; Jiefu Zheng ; Scott Matthews ; Alfred L. Nutall, et al.
"In vivo imaging and low-coherence interferometry of organ of Corti vibration", J. Biomed. Opt. 12(2), 021006 (April 12, 2007). ; http://dx.doi.org/10.1117/1.2717134


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