Research Papers

Cortical blood flow assessment with frequency-domain laser Doppler microscopy

[+] Author Affiliations
Michael Atlan, Benoît C. Forget, Albert C. Boccara

Université Pierre et Marie Curie, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris, Laboratoire d’Optique, CNRS UPR A0005, 10 rue Vauquelin, F-75231 Paris cedex 05, France

Tania Vitalis, Armelle Rancillac

École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris, Laboratoire de Neurobiologie et Diversité Cellulaire, CNRS UMR 7637, 10 rue Vauquelin, F-75231 Paris cedex 05, France

Andrew K. Dunn

University of Texas at Austin, Biomedical Engineering Department 1 University Station, CO800, Austin, Texas 78712-0238

Michel Gross

Ecole Normale Supérieure, Laboratoire Kastler-Brossel, UMR 8552 (ENS, CNRS, UMPC), 10 rue Lhomond, F-75231 Paris cedex 05, France

J. Biomed. Opt. 12(2), 024019 (April 26, 2007). doi:10.1117/1.2715184
History: Received July 13, 2006; Revised October 12, 2006; Accepted November 28, 2006; Published April 26, 2007
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We report the assessment of cerebral blood flow (CBF) changes with a wide-field laser Doppler imager based on a CCD camera detection scheme, in vivo, in mice. The setup enables the acquisition of data in minimally invasive conditions. In contrast with conventional laser Doppler velocimeters and imagers, the Doppler signature of moving scatterers is measured in the frequency domain, by detuning a heterodyne optical detection. The quadratic mean of the measured frequency shift is used as an indicator of CBF. We observe a significant variability of this indicator in an experiment designed to induce blood flow changes.

Figures in this Article
© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Michael Atlan ; Benoît C. Forget ; Albert C. Boccara ; Tania Vitalis ; Armelle Rancillac, et al.
"Cortical blood flow assessment with frequency-domain laser Doppler microscopy", J. Biomed. Opt. 12(2), 024019 (April 26, 2007). ; http://dx.doi.org/10.1117/1.2715184


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