Research Papers

Optical sensor for interstitial pH measurements

[+] Author Affiliations
Francesco Baldini, Ambra Giannetti, Andrea A. Mencaglia

Nello Carrara Institute of Applied Physics, CNR, Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy

J. Biomed. Opt. 12(2), 024024 (March 22, 2007). doi:10.1117/1.2714807
History: Received July 04, 2006; Revised December 18, 2006; Accepted December 18, 2006; Published March 22, 2007
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An optical fiber sensor for measuring the pH in interstitial fluid is described. Microdialysis is the approach followed for extracting the sample from the subcutaneous adipose tissue. The interstitial fluid drawn flows through a microfluidic circuit formed by a microdialysis catheter in series with a pH glass capillary. The pH indicator (phenol red) is covalently immobilized on the internal wall of the glass capillary. An optoelectronic unit that makes use of LEDs and photodetectors is connected to the sensing capillary by means of optical fibers. Optical fibers are used to connect the interrogating unit to the sensing capillary. A resolution of 0.03 pH units and an accuracy of 0.07 pH units are obtained. Preliminary in vivo tests are carried out in pigs with altered respiratory function.

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© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Francesco Baldini ; Ambra Giannetti and Andrea A. Mencaglia
"Optical sensor for interstitial pH measurements", J. Biomed. Opt. 12(2), 024024 (March 22, 2007). ; http://dx.doi.org/10.1117/1.2714807


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