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Research Papers

Finding the position of tumor inhomogeneities in a gel-like model of a human breast using 3-D pulsed digital holography

[+] Author Affiliations
Maria del Socorro Hernández-Montes, Carlos Pérez-López, Fernando Mendoza Santoyo

Centro de Investigaciones en Óptica, A.C., Loma del Bosque 115, Col. Lomas del Campestre León, Guanajuato, México 37150

J. Biomed. Opt. 12(2), 024027 (March 26, 2007). doi:10.1117/1.2717515
History: Received August 09, 2006; Revised November 27, 2006; Accepted December 20, 2006; Published March 26, 2007
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3-D pulsed digital holography is a noninvasive optical method used to measure the depth position of breast tumor tissue immersed in a semisolid gel model. A master gel without inhomogeneities is set to resonate at an 810 Hz frequency; then, an identically prepared gel with an inhomogeneity is interrogated with the same resonant frequency in the original setup. Comparatively, and using only an out-of-plane sensitive setup, gel surface displacement can be measured, evidencing an internal inhomogeneity. However, the depth position cannot be measured accurately, since the out-of-plane component has the contribution of in-plane surface displacements. With the information gathered, three sensitivity vectors can be obtained to separate contributions from x, y, and z vibration displacement components, individual displacement maps for the three orthogonal axes can be built, and the inhomogeneity’s depth position can be accurately measured. Then, the displacement normal to the gel surface is used to find the depth profile and its cross section. Results from the optical data obtained are compared and correlated to the inhomogeneity’s physically measured position. Depth position is found with an error smaller than 1%. The inhomogeneity and its position within the gel can be accurately found, making the method a promising noninvasive alternative to study mammary tumors.

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© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Maria del Socorro Hernández-Montes ; Carlos Pérez-López and Fernando Mendoza Santoyo
"Finding the position of tumor inhomogeneities in a gel-like model of a human breast using 3-D pulsed digital holography", J. Biomed. Opt. 12(2), 024027 (March 26, 2007). ; http://dx.doi.org/10.1117/1.2717515


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