Research Papers

Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints

[+] Author Affiliations
Zhen Yuan, Qizhi Zhang

University of Florida, Department of Biomedical Engineering, Gainesville, Florida 32611-6131

Eric Sobel

University of Florida, Division of Rheumatology, College of Medicine, Gainesville, Florida 32611

Huabei Jiang

University of Florida, Department of Biomedical Engineering, Gainesville, Florida 32611-6131

J. Biomed. Opt. 12(3), 034001 (May 21, 2007). doi:10.1117/1.2737420
History: Received March 30, 2006; Revised February 06, 2007; Accepted February 22, 2007; Published May 21, 2007
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This work presents a pilot study to show the potential of an emerging imaging modality, near-infrared diffuse optical tomography (DOT), for the diagnosis of osteoarthritis (OA). We report quantitative absorption and scattering images of joint tissue that allow for differentiation between diseased and healthy joints. An automatic, multichannel optical imaging system is used to image finger joints from two OA patients and three healthy volunteers. 3-D optical images of the joint tissue are recovered using a finite-element-based reconstruction algorithm. The reconstructed images demonstrate differences in optical properties at the joint region (cartilage/synovial fluid) between the OA and healthy joints. Quantitative analysis from the patients and healthy volunteers also indicate that the recovered joint sizes are consistent with those from x-ray findings. The results of this pilot study show potential for quantitative imaging and diagnosis of early OA by DOT.

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© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Zhen Yuan ; Qizhi Zhang ; Eric Sobel and Huabei Jiang
"Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints", J. Biomed. Opt. 12(3), 034001 (May 21, 2007). ; http://dx.doi.org/10.1117/1.2737420


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