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Research Papers

Discriminating basal cell carcinoma from perilesional skin using high wave-number Raman spectroscopy

[+] Author Affiliations
Annieke Nijssen, Kees Maquelin

Erasmus MC, Center for Optical Diagnostics and Therapy, Department of Dermatology, Rotterdam, The Netherlands

Luis F. Santos

Erasmus MC, Center for Optical Diagnostics and Therapy, Department of Dermatology, Rotterdam, The Netherlands and Instituto Superior Téchnico, Department of Materials, Lisbon, Portugal

Peter J. Caspers, Tom C. Bakker Schut

Erasmus MC, Center for Optical Diagnostics and Therapy, Department of Dermatology, Rotterdam, The Netherlands

Jan C. den Hollander

Erasmus MC, Department of Pathology, Rotterdam, The Netherlands

Martino H. A. Neumann, Gerwin J. Puppels

Erasmus MC, Center for Optical Diagnostics and Therapy, Department of Dermatology, Rotterdam, The Netherlands

J. Biomed. Opt. 12(3), 034004 (June 22, 2007). doi:10.1117/1.2750287
History: Received November 06, 2006; Revised February 27, 2007; Accepted February 28, 2007; Published June 22, 2007
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An expanding body of literature suggests Raman spectroscopy is a promising tool for skin cancer diagnosis and in-vivo tumor border demarcation. The development of an in-vivo diagnostic tool is, however, hampered by the fact that construction of fiber optic probes suitable for Raman spectroscopy in the so-called fingerprint region is complicated. In contrast, the use of the high wave-number region allows for fiber optic probes with a very simple design. We investigate whether high wave-number Raman spectroscopy (2800 to 3125cm1) is able to provide sufficient information for noninvasive discrimination between basal cell carcinoma (BCC) and noninvolved skin. Using a simple fiber optic probe, Raman spectra are obtained from 19 BCC biopsy specimens and 9 biopsy specimens of perilesional skin. A linear discriminant analysis (LDA)-based tissue classification model is developed, which discriminates between BCC and noninvolved skin with high accuracy. This is a crucial step in the development of clinical dermatological applications based on fiber optic Raman spectroscopy.

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© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Annieke Nijssen ; Kees Maquelin ; Luis F. Santos ; Peter J. Caspers ; Tom C. Bakker Schut, et al.
"Discriminating basal cell carcinoma from perilesional skin using high wave-number Raman spectroscopy", J. Biomed. Opt. 12(3), 034004 (June 22, 2007). ; http://dx.doi.org/10.1117/1.2750287


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