Research Papers

Performance of an exhaled nitric oxide and carbon dioxide sensor using quantum cascade laser-based integrated cavity output spectroscopy

[+] Author Affiliations
Matthew R. McCurdy

Rice University, Rice Quantum Institute, 6100 Main Street, Houston, Texas 77005 and Baylor College of Medicine, Medical Scientist Training Program, 1 Baylor Plaza, Houston, Texas 77030

Yury Bakhirkin, Gerard Wysocki, Frank K. Tittel

Rice University, Rice Quantum Institute, 6100 Main Street, Houston, Texas 77005

J. Biomed. Opt. 12(3), 034034 (June 11, 2007). doi:10.1117/1.2747608
History: Received December 09, 2006; Revised February 24, 2007; Accepted February 26, 2007; Published June 11, 2007
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Exhaled nitric oxide (NO) is an important biomarker in asthma and other respiratory disorders. The optical performance of a NOCO2 sensor employing integrated cavity output spectroscopy (ICOS) with a quantum cascade laser operating at 5.22μm capable of real-time NO and CO2 measurements in a single breath cycle is reported. A NO noise-equivalent concentration of 0.4ppb within a 1-sec integration time is achieved. The off-axis ICOS sensor performance is compared to a chemiluminescent NO analyzer and a nondispersive infrared (NDIR) CO2 absorption capnograph. Differences between the gas analyzers are assessed by the Bland-Altman method to estimate the expected variability between the gas sensors. The off-axis ICOS sensor measurements are in good agreement with the data acquired with the two commercial gas analyzers. This work demonstrates the performance characteristics and merits of mid-infrared spectroscopy for exhaled breath analysis.

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© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Matthew R. McCurdy ; Yury Bakhirkin ; Gerard Wysocki and Frank K. Tittel
"Performance of an exhaled nitric oxide and carbon dioxide sensor using quantum cascade laser-based integrated cavity output spectroscopy", J. Biomed. Opt. 12(3), 034034 (June 11, 2007). ; http://dx.doi.org/10.1117/1.2747608


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