Research Papers

Optical method for real-time monitoring of drug concentrations facilitates the development of novel methods for drug delivery to brain tissue

[+] Author Affiliations
Roberto Reif

Boston University, Department of Biomedical Engineering, 44 Cummington Street, Boston, Massachusetts 02215

Mei Wang, Shailendra Joshi

Columbia University College of Physicians and Surgeons, Department of Anesthesiology, New York, New York 10032

Ousama A’Amar

Boston University, Department of Biomedical Engineering, 44 Cummington Street, Boston, Massachusetts 02215

Irving J. Bigio

Boston University, Departments of Biomedical Engineering and Electrical & Computer Engineering, 44 Cummington Street, Boston, Massachusetts 02215

J. Biomed. Opt. 12(3), 034036 (May 31, 2007). doi:10.1117/1.2744025
History: Received February 05, 2007; Revised March 13, 2007; Accepted March 29, 2007; Published May 31, 2007
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The understanding of drug delivery to organs, such as the brain, has been hampered by the inability to measure tissue drug concentrations in real time. We report an application of an optical spectroscopy technique that monitors in vivo the real-time drug concentrations in small volumes of brain tissue. This method will facilitate development of new protocols for delivery of drugs to treat brain cancers. The delivery of many anticancer drugs to the brain is limited by the presence of the blood-brain barrier (BBB). Mitoxantrone (MTX) is a water-soluble anticancer drug that poorly penetrates the BBB. It is preliminarily determined in an animal model that the brain tissue uptake of chemotherapy agents—in this demonstration, MTX—delivered intra-arterially is enhanced when the BBB is disrupted.

Figures in this Article
© 2007 Society of Photo-Optical Instrumentation Engineers

Topics

Brain ; Tissues ; Blood

Citation

Roberto Reif ; Mei Wang ; Shailendra Joshi ; Ousama A’Amar and Irving J. Bigio
"Optical method for real-time monitoring of drug concentrations facilitates the development of novel methods for drug delivery to brain tissue", J. Biomed. Opt. 12(3), 034036 (May 31, 2007). ; http://dx.doi.org/10.1117/1.2744025


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