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Special Section on Optical Coherence Tomography in Ophthalmology

Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies

[+] Author Affiliations
Maciej Szkulmowski, Maciej Wojtkowski

Nicolaus Copernicus University, Institute of Physics, ul. Grudziadzka 5/7, PL-87-100 Torun, Poland

Bartosz Sikorski

Nicolaus Copernicus University, Collegium Medicum, Department of Ophthalmology, Curie-Sklodowskiej 9, PL-85-094 Bydgoszcz, Poland

Tomasz Bajraszewski

Nicolaus Copernicus University, Institute of Physics, ul. Grudziadzka 5/7, PL-87-100 Torun, Poland

Vivek J. Srinivasan

Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Cambridge, Massachusetts 02139

Anna Szkulmowska

Nicolaus Copernicus University, Institute of Physics, ul. Grudziadzka 5/7, PL-87-100 Torun, Poland

Jakub J. Kałużny

Nicolaus Copernicus University, Collegium Medicum, Department of Ophthalmology, Curie-Sklodowskiej 9, PL-85-094 Bydgoszcz, Poland

James G. Fujimoto

Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Cambridge, Massachusetts 02139

Andrzej Kowalczyk

Nicolaus Copernicus University, Institute of Physics, ul. Grudziadzka 5/7, PL-87-100 Torun, Poland

J. Biomed. Opt. 12(4), 041207 (August 17, 2007). doi:10.1117/1.2771569
History: Received October 13, 2006; Revised April 25, 2007; Accepted April 30, 2007; Published August 17, 2007
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We present a computationally efficient, semiautomated method for analysis of posterior retinal layers in three-dimensional (3-D) images obtained by spectral optical coherence tomography (SOCT). The method consists of two steps: segmentation of posterior retinal layers and analysis of their thickness and distance from an outer retinal contour (ORC), which is introduced to approximate the normal position of external interface of the healthy retinal pigment epithelium (RPE). The algorithm is shown to effectively segment posterior retina by classifying every pixel in the SOCT tomogram using the similarity of its surroundings to a reference set of model pixels from user-selected area(s). Operator intervention is required to assess the quality of segmentation. Thickness and distance maps from the segmented layers and their analysis are presented for healthy and pathological retinas.

Figures in this Article
© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Maciej Szkulmowski ; Maciej Wojtkowski ; Bartosz Sikorski ; Tomasz Bajraszewski ; Vivek J. Srinivasan, et al.
"Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies", J. Biomed. Opt. 12(4), 041207 (August 17, 2007). ; http://dx.doi.org/10.1117/1.2771569


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