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Special Section on Optical Coherence Tomography in Ophthalmology

Enhancing the signal-to-noise ratio in ophthalmic optical coherence tomography by image registration—method and clinical examples

[+] Author Affiliations
Thomas Martini Jørgensen, Jakob Thomadsen

Technical University of Denmark, Riso National Laboratory, Optics and Plasma Research Department, Roskilde, Denmark

Ulrik Christensen, Wael Soliman, Birgit Sander

University of Copenhagen, Glostrup Hospital, Department of Ophthalmology, Copenhagen, Denmark

J. Biomed. Opt. 12(4), 041208 (August 23, 2007). doi:10.1117/1.2772879
History: Received November 04, 2006; Revised February 16, 2007; Accepted February 21, 2007; Published August 23, 2007
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Optical coherence tomography (OCT) has already proven an important clinical tool for imaging and diagnosing retinal diseases. Concerning the standard commercial ophthalmic OCT systems, speckle noise is a limiting factor with respect to resolving relevant retinal features. We demonstrate successful suppression of speckle noise from mutually aligning a series of in vivo OCT recordings obtained from the same retinal target using the Stratus system from Humphrey-Zeiss. Our registration technique is able to account for the axial movements experienced during recording as well as small transverse movements of the scan line from one scan to the next. The algorithm is based on a regularized shortest path formulation for a directed graph on a map formed by interimage (B-scan) correlations. The resulting image enhancement typically increases the contrast-to-noise ratio (CNR) with a factor of three or more and facilitates segmentation and quantitative characterization of pathologies. The method is currently successfully being applied by medical doctors in a number of specific retinal case studies.

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© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Thomas Martini Jørgensen ; Jakob Thomadsen ; Ulrik Christensen ; Wael Soliman and Birgit Sander
"Enhancing the signal-to-noise ratio in ophthalmic optical coherence tomography by image registration—method and clinical examples", J. Biomed. Opt. 12(4), 041208 (August 23, 2007). ; http://dx.doi.org/10.1117/1.2772879


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