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Special Section on Optical Coherence Tomography in Ophthalmology

Evaluation of potential image acquisition pitfalls during optical coherence tomography and their influence on retinal image segmentation

[+] Author Affiliations
Gábor Márk Somfai

Semmelweis University, Faculty of Medicine, Department of Ophthalmology, Mária Street 39, Budapest, Hungary 1085

Harry M. Salinas

Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029

Carmen A. Puliafito, Delia Cabrera Fernández

University of Miami, Miller School of Medicine, Bascom Palmer Eye Institute, Miami, Florida 33136

J. Biomed. Opt. 12(4), 041209 (August 30, 2007). doi:10.1117/1.2774827
History: Received October 31, 2006; Revised March 23, 2007; Accepted June 29, 2007; Published August 30, 2007
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The development of improved segmentation algorithms for more consistently accurate detection of retinal boundaries is a potentially useful solution to the limitations of existing optical coherence tomography (OCT) software. We modeled artifacts related to operator errors that may normally occur during OCT imaging and evaluated their influence on segmentation results using a novel segmentation algorithm. These artifacts included: defocusing, depolarization, decentration, and a combination of defocusing and depolarization. Mean relative reflectance and average thickness of the automatically extracted intraretinal layers was then measured. Our results show that defocusing and depolarization errors together have the greatest altering effect on all measurements and on segmentation accuracy. A marked decrease in mean relative reflectance and average thickness was observed due to depolarization artifact in all intraretinal layers, while defocus resulted in a less-marked decrease. Decentration resulted in a marked but not significant change in average thickness. Our study demonstrates that care must be taken for good-quality imaging when measurements of intraretinal layers using the novel algorithm are planned in future studies. An awareness of these pitfalls and their possible solutions is crucial for obtaining a better quantitative analysis of clinically relevant features of retinal pathology.

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© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Gábor Márk Somfai ; Harry M. Salinas ; Carmen A. Puliafito and Delia Cabrera Fernández
"Evaluation of potential image acquisition pitfalls during optical coherence tomography and their influence on retinal image segmentation", J. Biomed. Opt. 12(4), 041209 (August 30, 2007). ; http://dx.doi.org/10.1117/1.2774827


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