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Special Section on Optical Coherence Tomography in Ophthalmology

Spectral oximetry assessed with high-speed ultra-high-resolution optical coherence tomography

[+] Author Affiliations
Larry Kagemann

University of Pittsburgh School of Medicine, Department of Ophthalmology, Ophthalmology and Visual Sciences Research Center, UPMC Eye Center, Eye and Ear Institute, Pittsburgh, Pennsylvania 15213 and University of Pittsburgh School of Engineering, Department of Bioengineering, Pittsburgh, Pennsylvania 15213

Gadi Wollstein

University of Pittsburgh School of Medicine, Department of Ophthalmology, Ophthalmology and Visual Sciences Research Center, UPMC Eye Center, Eye and Ear Institute, Pittsburgh, Pennsylvania 15213

Maciej Wojtkowski

Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Cambridge, Massachusetts 02139 and Nicolaus Copernicus University, Institute of Physics, Torun, Poland 87-100

Hiroshi Ishikawa

University of Pittsburgh School of Medicine, Department of Ophthalmology, Ophthalmology and Visual Sciences Research Center, UPMC Eye Center, Eye and Ear Institute, Pittsburgh, Pennsylvania 15213 and University of Pittsburgh School of Engineering, Department of Bioengineering, Pittsburgh, Pennsylvania 15213

Kelly A. Townsend

University of Pittsburgh School of Medicine, Department of Ophthalmology, Ophthalmology and Visual Sciences Research Center, UPMC Eye Center, Eye and Ear Institute, Pittsburgh, Pennsylvania 15213

Michelle L. Gabriele

University of Pittsburgh School of Medicine, Department of Ophthalmology, Ophthalmology and Visual Sciences Research Center, UPMC Eye Center, Eye and Ear Institute, Pittsburgh, Pennsylvania 15213 and University of Pittsburgh School of Engineering, Department of Bioengineering, Pittsburgh, Pennsylvania 15213

Vivek J. Srinivasan, James G. Fujimoto

Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Cambridge, Massachusetts 02139

Joel S. Schuman

University of Pittsburgh School of Medicine, Department of Ophthalmology, Ophthalmology and Visual Sciences Research Center, UPMC Eye Center, Eye and Ear Institute, Pittsburgh, Pennsylvania 15213 and University of Pittsburgh School of Engineering, Department of Bioengineering, Pittsburgh, Pennsylvania 15213

J. Biomed. Opt. 12(4), 041212 (November 07, 2006June 11, 2007July 16, 2007July 16, 2007August 13, 2007). doi:10.1117/1.2772655
History: Received November 07, 2006; Revised June 11, 2007; Revised July 16, 2007; Accepted July 16, 2007; Published August 13, 2007
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We use Fourier domain optical coherence tomography (OCT) data to assess retinal blood oxygen saturation. Three-dimensional disk-centered retinal tissue volumes were assessed in 17 normal healthy subjects. After removing DC and low-frequency a-scan components, an OCT fundus image was created by integrating total reflectance into a single reflectance value. Thirty fringe patterns were sampled; 10 each from the edge of an artery, adjacent tissue, and the edge of a vein, respectively. A-scans were recalculated, zeroing the DC term in the power spectrum, and used for analysis. Optical density ratios (ODRs) were calculated as ODRArt=ln(Tissue855Art855)ln(Tissue805Art805) and ODRVein=ln(Tissue855Vein855)ln(Tissue805Vein805) with Tissue, Art, and Vein representing total a-scan reflectance at the 805- or 855-nm centered bandwidth. Arterial and venous ODRs were compared by the Wilcoxon signed rank test. Arterial ODRs were significantly greater than venous ODRs (1.007±2.611 and 1.434±4.310, respectively; p=0.0217) (mean±standard deviation). A difference between arterial and venous blood saturation was detected. This suggests that retinal oximetry may possibly be added as a metabolic measurement in structural imaging devices.

Figures in this Article
© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Larry Kagemann ; Gadi Wollstein ; Maciej Wojtkowski ; Hiroshi Ishikawa ; Kelly A. Townsend, et al.
"Spectral oximetry assessed with high-speed ultra-high-resolution optical coherence tomography", J. Biomed. Opt. 12(4), 041212 (November 07, 2006June 11, 2007July 16, 2007July 16, 2007August 13, 2007). ; http://dx.doi.org/10.1117/1.2772655


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