Special Section on Optical Coherence Tomography in Ophthalmology

Vectorial reconstruction of retinal blood flow in three dimensions measured with high resolution resonant Doppler Fourier domain optical coherence tomography

[+] Author Affiliations
Roland Michaely, Adrian H. Bachmann, Martin L. Villiger, Cédric Blatter, Theo Lasser, Rainer A. Leitgeb

École Polytechnique Fédérale de Lausanne, Laboratoire d’Optique Biomédicale, CH-1015 Lausanne, Switzerland

J. Biomed. Opt. 12(4), 041213 (September 05, 2007). doi:10.1117/1.2771553
History: Received November 23, 2006; Revised May 01, 2007; Accepted May 24, 2007; Published September 05, 2007
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Resonant Doppler Fourier domain optical coherence tomography (FDOCT) is a functional imaging tool for extracting tissue flow. The method is based on the effect of interference fringe blurring in spectrometer-based FDOCT, where the path difference between structure and reference changes during camera integration. If the reference path length is changed in resonance with the Doppler frequency of the sample flow, the signals of resting structures will be suppressed, whereas the signals of blood flow are enhanced. This allows for an easy extraction of vascularization structure. Conventional flow velocity analysis extracts only the axial flow component, which strongly depends on the orientation of the vessel with respect to the incident light. We introduce an algorithm to extract the vessel geometry within the 3-D data volume. The algorithm calculates the angular correction according to the local gradients of the vessel orientations. We apply the algorithm on a measured 3-D resonant Doppler dataset. For validation of the reproducibility, we compare two independently obtained 3-D flow maps of the same volunteer and region.

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© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Roland Michaely ; Adrian H. Bachmann ; Martin L. Villiger ; Cédric Blatter ; Theo Lasser, et al.
"Vectorial reconstruction of retinal blood flow in three dimensions measured with high resolution resonant Doppler Fourier domain optical coherence tomography", J. Biomed. Opt. 12(4), 041213 (September 05, 2007). ; http://dx.doi.org/10.1117/1.2771553


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