Special Section on Optical Coherence Tomography in Ophthalmology

Real-time spectral domain Doppler optical coherence tomography and investigation of human retinal vessel autoregulation

[+] Author Affiliations
Bradley A. Bower, Mingtao Zhao

Duke University, Department of Biomedical Engineering, Durham, North Carolina 27708

Robert J. Zawadzki

University of California, Davis, Department of Ophthalmology and Vision Science, Sacramento, California 95817

Joseph A. Izatt

Duke University, Department of Biomedical Engineering, Durham, North Carolina 27708

J. Biomed. Opt. 12(4), 041214 (August 20, 2007). doi:10.1117/1.2772877
History: Received November 05, 2006; Revised April 04, 2007; Accepted April 19, 2007; Published August 20, 2007
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Investigation of the autoregulatory mechanism of human retinal perfusion is conducted with a real-time spectral domain Doppler optical coherence tomography (SDOCT) system. Volumetric, time-sequential, and Doppler flow imaging are performed in the inferior arcade region on normal healthy subjects breathing normal room air and 100% oxygen. The real-time Doppler SDOCT system displays fully processed, high-resolution [512 (axial)×1000 (lateral) pixels] B scans at 17framessec in volumetric and time-sequential imaging modes, and also displays fully processed overlaid color Doppler flow images comprising 512 (axial)×500 (lateral) pixels at 6framessec. Data acquired following 5min of 100% oxygen inhalation is compared with that acquired 5min postinhalation for four healthy subjects. The average vessel constriction across the population is 16±26% after oxygen inhalation with a dilation of 36±54% after a return to room air. The flow decreases by 6±20% in response to oxygen and in turn increases by 21±28% as flow returns to normal in response to room air. These trends are in agreement with those previously reported using laser Doppler velocimetry to study retinal vessel autoregulation. Doppler flow repeatability data are presented to address the high standard deviations in the measurements.

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© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Bradley A. Bower ; Mingtao Zhao ; Robert J. Zawadzki and Joseph A. Izatt
"Real-time spectral domain Doppler optical coherence tomography and investigation of human retinal vessel autoregulation", J. Biomed. Opt. 12(4), 041214 (August 20, 2007). ; http://dx.doi.org/10.1117/1.2772877


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