Special Section on Optical Coherence Tomography in Ophthalmology

In vivo total retinal blood flow measurement by Fourier domain Doppler optical coherence tomography

[+] Author Affiliations
Yimin Wang

University of Southern California, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, 1355 San Pablo Street, DVRC 160B, Los Angeles, California 90033

Bradley A. Bower, Joseph A. Izatt

Duke University, Department of Biomedical Engineering, 136 Hudson Hall, Box 90281, Campus, Durham, North Carolina 27708

Ou Tan, David Huang

University of Southern California, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, 1355 San Pablo Street, DVRC 160B, Los Angeles, California 90033

J. Biomed. Opt. 12(4), 041215 (August 21, 2007). doi:10.1117/1.2772871
History: Received October 31, 2006; Revised March 02, 2007; Accepted March 09, 2007; Published August 21, 2007
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There is considerable interest in new methods for the assessment of retinal blood flow for the diagnosis of eye diseases. We present in vivo normal human volumetric retinal flow measurement using Fourier domain Doppler optical coherence tomography. We used a dual-plane scanning pattern to determine the angle between the blood flow and the scanning beam in order to measure total flow velocity. Volumetric flow in each blood vessel around the optic nerve head was integrated in one cardiac cycle in each measurement. Measurements were performed in the right eye of one human subject. The measured venous flow velocity ranged from 16.26mms to 29.7mms. The arterial flow velocity ranged from 38.35mms to 51.13mms. The total retinal venous and arterial flow both added up to approximately 54μlmin. We believe this is the first demonstration of total retinal blood flow measurement using the OCT technique.

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© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Yimin Wang ; Bradley A. Bower ; Joseph A. Izatt ; Ou Tan and David Huang
"In vivo total retinal blood flow measurement by Fourier domain Doppler optical coherence tomography", J. Biomed. Opt. 12(4), 041215 (August 21, 2007). ; http://dx.doi.org/10.1117/1.2772871


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