Research Papers

Targeting spectral signatures of progressively dysplastic stratified epithelia using angularly variable fiber geometry in reflectance Monte Carlo simulations

[+] Author Affiliations
Adrien Wang, Vengadesan Nammalavar, Rebekah Drezek

Rice University, Department of Bioengineering, Houston, Texas 77251-1892

J. Biomed. Opt. 12(4), 044012 (August 13, 2007). doi:10.1117/1.2769328
History: Received November 09, 2006; Revised April 02, 2007; Accepted April 14, 2007; Published August 13, 2007
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A key component of accurate spectroscopic-based cancer diagnostics is the ability to differentiate spectral variations resulting from epithelial tissue dysplasia. Such measurement may be enhanced by discretely probing the optical properties of the epithelial tissue where the morphological and biochemical features vary according to tissue depths. More precisely, layer-specific changes in tissue optical properties correlated to cellular dysplasia can be determined by conventional reflectance spectroscopy when it is coupled with angularly variable fiber geometry. Thus, this study addresses how angularly variable fiber geometry can resolve spatially specific spectral signatures of tissue pathology by interpreting and analyzing the reflectance spectra of increasingly dysplastic epithelial tissue in reflectance-mode Monte Carlo simulation. Specifically, by increasing the obliquity of the collection fibers from 0 to 40deg in the direction facing toward the illumination fiber, the spectral sensitivity to tissue abnormalities in the epithelial layer is thereby improved, whereas orthogonal fibers are more sensitive to the changes in the stromal layer.

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© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Adrien Wang ; Vengadesan Nammalavar and Rebekah Drezek
"Targeting spectral signatures of progressively dysplastic stratified epithelia using angularly variable fiber geometry in reflectance Monte Carlo simulations", J. Biomed. Opt. 12(4), 044012 (August 13, 2007). ; http://dx.doi.org/10.1117/1.2769328


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