Research Papers

Sensitive biosensor array using surface plasmon resonance on metallic nanoslits

[+] Author Affiliations
Kuang-Li Lee

Academia Sinica, Research Center for Applied Sciences, 128, Section 2, Academia Road, Nankang, Taipei 11529, Taiwan and National Taiwan University, Graduate Institute of Electro-Optical Engineering, Department of Electrical Engineering, Taipei, Taiwan

Chia-Wei Lee

Academia Sinica, Research Center for Applied Sciences, 128, Section 2, Academia Road, Nankang, Taipei 11529, Taiwan

Way-Seen Wang

National Taiwan University, Graduate Institute of Electro-Optical Engineering, Department of Electrical Engineering, Taipei, Taiwan

Pei-Kuen Wei

Academia Sinica, Research Center for Applied Sciences, 128, Section 2, Academia Road, Nankang, Taipei 11529, Taiwan and National Taiwan Ocean University, Department of Optoelectronics, Keelung, Taiwan

J. Biomed. Opt. 12(4), 044023 (August 31, 2007). doi:10.1117/1.2772296
History: Received November 24, 2006; Revised March 15, 2007; Accepted March 15, 2007; Published August 31, 2007
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Chip-based biosensor arrays for label-free and high-throughput detection were fabricated and tested. The sensor array was composed of a 150-nm-thick, 50-nm-gap, and 600-nm-period gold nanoslits. Each array size was 100μm×100μm. A transverse-magnetic polarized wave in these metallic nanostructures generated resonant surface plasmons at a wavelength of about 800nm in a water environment. Using the resonant wavelength shift in the nanoslit array, we achieved detection sensitivity up to 668nm per refractive index unit, about 1.7 times larger than that reported on an array of nanoholes. An antigen–antibody interaction experiment in an aqueous environment verified the sensitivity in a surface binding event.

Figures in this Article
© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Kuang-Li Lee ; Chia-Wei Lee ; Way-Seen Wang and Pei-Kuen Wei
"Sensitive biosensor array using surface plasmon resonance on metallic nanoslits", J. Biomed. Opt. 12(4), 044023 (August 31, 2007). ; http://dx.doi.org/10.1117/1.2772296


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