Special Section on Optical Diagnostic Imaging from Bench to Bedside Reviews

Optical coherence tomography: a review of clinical development from bench to bedside

[+] Author Affiliations
Adam M. Zysk

University of Illinois at Urbana-Champaign, Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, Biophotonics Imaging Laboratory, 405 North Mathews Avenue, Urbana, Illinois 61801

Freddy T. Nguyen

University of Illinois at Urbana-Champaign, Beckman Institute for Advanced Science and Technology, Department of Chemistry College of Medicine,Biophotonics Imaging Laboratory, 405 North Mathews Avenue, Urbana, Illinois 61801

Amy L. Oldenburg, Daniel L. Marks

University of Illinois at Urbana-Champaign, Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, Biophotonics Imaging Laboratory, 405 North Mathews Avenue, Urbana, Illinois 61801

Stephen A. Boppart

Mills Breast Cancer Institute, Carle Foundation Hospital and Carle Clinic Association, Urbana, Illinois 61801and University of Illinois at Urbana-Champaign, Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, Biophotonics Imaging Laboratory , 405 North Mathews Avenue, Urbana, Illinois 61801

J. Biomed. Opt. 12(5), 051403 (October 24, 2007). doi:10.1117/1.2793736
History: Received January 30, 2007; Revised June 18, 2007; Accepted June 18, 2007; Published October 24, 2007
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Since its introduction, optical coherence tomography (OCT) technology has advanced from the laboratory bench to the clinic and back again. Arising from the fields of low coherence interferometry and optical time- and frequency-domain reflectometry, OCT was initially demonstrated for retinal imaging and followed a unique path to commercialization for clinical use. Concurrently, significant technological advances were brought about from within the research community, including improved laser sources, beam delivery instruments, and detection schemes. While many of these technologies improved retinal imaging, they also allowed for the application of OCT to many new clinical areas. As a result, OCT has been clinically demonstrated in a diverse set of medical and surgical specialties, including gastroenterology, dermatology, cardiology, and oncology, among others. The lessons learned in the clinic are currently spurring a new set of advances in the laboratory that will again expand the clinical use of OCT by adding molecular sensitivity, improving image quality, and increasing acquisition speeds. This continuous cycle of laboratory development and clinical application has allowed the OCT technology to grow at a rapid rate and represents a unique model for the translation of biomedical optics to the patient bedside. This work presents a brief history of OCT development, reviews current clinical applications, discusses some clinical translation challenges, and reviews laboratory developments poised for future clinical application.

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© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Adam M. Zysk ; Freddy T. Nguyen ; Amy L. Oldenburg ; Daniel L. Marks and Stephen A. Boppart
"Optical coherence tomography: a review of clinical development from bench to bedside", J. Biomed. Opt. 12(5), 051403 (October 24, 2007). ; http://dx.doi.org/10.1117/1.2793736


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