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Special Section on Optical Diagnostic Imaging from Bench to Bedside Vascular Imaging

Dynamic optical imaging of vascular and metabolic reactivity in rheumatoid joints

[+] Author Affiliations
Joseph M. Lasker, Christopher J. Fong, Daniel T. Ginat

Columbia University, Departments of Biomedical Engineering and Radiology, 500 West 120th Street, ET351 Mudd Building, MC8904, New York, New York 10027

Edward Dwyer

Columbia University, Department of Medicine, 500 West 120th Street, New York, New York 10027

Andreas H. Hielscher

Columbia University, Departments of Biomedical Engineering and Radiology, 500 West 120th Street, ET351 Mudd Building, MC8904, New York, New York 10027

J. Biomed. Opt. 12(5), 052001 (December 15, 2006May 08, 2007May 17, 2007November 02, 2007). doi:10.1117/1.2798757
History: Received December 15, 2006; Revised May 08, 2007; Accepted May 17, 2007; Published November 02, 2007
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Dynamic optical imaging is increasingly applied to clinically relevant areas such as brain and cancer imaging. In this approach, some external stimulus is applied and changes in relevant physiological parameters (e.g., oxy- or deoxyhemoglobin concentrations) are determined. The advantage of this approach is that the prestimulus state can be used as a reference or baseline against which the changes can be calibrated. Here we present the first application of this method to the problem of characterizing joint diseases, especially effects of rheumatoid arthritis (RA) in the proximal interphalangeal finger joints. Using a dual-wavelength tomographic imaging system together with previously implemented model-based iterative image reconstruction schemes, we have performed initial dynamic imaging case studies on a limited number of healthy volunteers and patients diagnosed with RA. Focusing on three cases studies, we illustrated our major finds. These studies support our hypothesis that differences in the vascular reactivity exist between affected and unaffected joints.

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© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Joseph M. Lasker ; Edward Dwyer ; Andreas H. Hielscher ; Christopher J. Fong and Daniel T. Ginat
"Dynamic optical imaging of vascular and metabolic reactivity in rheumatoid joints", J. Biomed. Opt. 12(5), 052001 (December 15, 2006May 08, 2007May 17, 2007November 02, 2007). ; http://dx.doi.org/10.1117/1.2798757


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