Research Papers

Gas monitoring in human sinuses using tunable diode laser spectroscopy

[+] Author Affiliations
Linda Persson, Mats Andersson, Märta Cassel-Engquist

Lund University, Division of Atomic Physics, P.O. Box 118, SE-221 00 Lund, Sweden

Katarina Svanberg

Lund University Hospital, Department of Oncology, SE-221 85 Lund, Sweden

Sune Svanberg

Lund University, Division of Atomic Physics, P.O. Box 118, SE-221 00 Lund, Sweden

J. Biomed. Opt. 12(5), 054001 (September 12, 2007). doi:10.1117/1.2777189
History: Received March 23, 2007; Revised June 11, 2007; Accepted June 11, 2007; Published September 12, 2007
Text Size: A A A

We demonstrate a novel nonintrusive technique based on tunable diode laser absorption spectroscopy to investigate human sinuses in vivo. The technique relies on the fact that free gases have spectral imprints that are about 10.000 times sharper than spectral structures of the surrounding tissue. Two gases are detected; molecular oxygen at 760nm and water vapor at 935nm. Light is launched fiber optically into the tissue in close proximity to the particular maxillary sinus under study. When investigating the frontal sinuses, the fiber is positioned onto the caudal part of the frontal bone. Multiply scattered light in both cases is detected externally by a handheld probe. Molecular oxygen is detected in the maxillary sinuses on 11 volunteers, of which one had constantly recurring sinus problems. Significant oxygen absorption imprint differences can be observed between different volunteers and also left-right asymmetries. Water vapor can also be detected, and by normalizing the oxygen signal on the water vapor signal, the sinus oxygen concentration can be assessed. Gas exchange between the sinuses and the nasal cavity is also successfully demonstrated by flushing nitrogen through the nostril. Advantages over current ventilation assessment methods using ionizing radiation are pointed out.

Figures in this Article
© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Linda Persson ; Mats Andersson ; Märta Cassel-Engquist ; Katarina Svanberg and Sune Svanberg
"Gas monitoring in human sinuses using tunable diode laser spectroscopy", J. Biomed. Opt. 12(5), 054001 (September 12, 2007). ; http://dx.doi.org/10.1117/1.2777189


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.