Research Papers

Receiver operating characteristic and location analysis of simulated near-infrared tomography images

[+] Author Affiliations
Xiaomei Song, Brian W. Pogue, Hamid Dehghani, Shudong Jiang, Keith D. Paulsen

Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755

Tor D. Tosteson

Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756

J. Biomed. Opt. 12(5), 054013 (November 01, 2007). doi:10.1117/1.2799197
History: Received April 12, 2007; Revised June 02, 2007; Accepted June 05, 2007; Published November 01, 2007
Text Size: A A A

Receiver operating characteristic (ROC) analysis was performed on simulated near-infrared tomography images, using both human observer and contrast-to-noise ratio (CNR) computational assessment, for application in breast cancer imaging. In the analysis, a nonparametric approach was applied for estimating the ROC curves. Human observer detection of objects had superior capability to localize the presence of heterogeneities when the objects were small with high contrast, with a minimum detectable threshold of CNR near 3.0 to 3.3 in the images. Human observers were able to detect heterogeneities in the images below a size limit of 4mm, yet could not accurately find the location of these objects when they were below 10mm diameter. For large objects, the lower limit of a detectable contrast limit was near 10% increase relative to the background. The results also indicate that iterations of the nonlinear reconstruction algorithm beyond 4 did not significantly improve the human detection ability, and degraded the overall localization ability for the objects in the image, predominantly by increasing the noise in the background. Interobserver variance performance in detecting objects in these images was low, suggesting that because of the low spatial resolution, detection tasks with NIR tomography is likely consistent between human observers.

Figures in this Article
© 2007 Society of Photo-Optical Instrumentation Engineers

Citation

Xiaomei Song ; Brian W. Pogue ; Hamid Dehghani ; Shudong Jiang ; Keith D. Paulsen, et al.
"Receiver operating characteristic and location analysis of simulated near-infrared tomography images", J. Biomed. Opt. 12(5), 054013 (November 01, 2007). ; http://dx.doi.org/10.1117/1.2799197


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.