Research Papers

In vivo determination of skin near-infrared optical properties using diffuse optical spectroscopy

[+] Author Affiliations
Sheng-Hao Tseng, Alexander Grant, Anthony J. Durkin

University of California, Irvine, Beckman Laser Institute, Laser Microbeam and Medical Program, Irvine, California 92617

J. Biomed. Opt. 13(1), 014016 (January 14, 2008). doi:10.1117/1.2829772
History: Received September 15, 2006; Revised October 15, 2007; Accepted October 16, 2007; Published January 14, 2008
Text Size: A A A

We develop a superficial diffusing probe with a 3mm source-detector separation that can be used in combination with diffuse optical spectroscopic (DOS) methods to noninvasively determine full-spectrum optical properties of superficial in vivo skin in the wavelength range from 650 to 1000nm. This new probe uses a highly scattering layer to diffuse photons emitted from a collimated light source and relies on a two-layer diffusion model to determine tissue absorption coefficient μa and reduced scattering coefficient μs. By employing the probe to measure two-layer phantoms that mimic the optical properties of skin, we demonstrate that the probe has an interrogation depth of 1 to 2mm. We carry out SSFDPM (steady state frequency-domain photon migration) measurements using this new probe on the volar forearm and palm of 15 subjects, including five subjects of African descent, five Asians, and five Caucasians. The optical properties of in vivo skin determined using the superficial diffusing probe show considerable similarity to published optical properties of carefully prepared ex vivoepidermis+dermis.

Figures in this Article
© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Sheng-Hao Tseng ; Alexander Grant and Anthony J. Durkin
"In vivo determination of skin near-infrared optical properties using diffuse optical spectroscopy", J. Biomed. Opt. 13(1), 014016 (January 14, 2008). ; http://dx.doi.org/10.1117/1.2829772


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.