Special Section on Optical Clearing of Tissues and Cells

Enhancement of optical skin clearing efficacy using a microneedle roller

[+] Author Affiliations
Jinhee Yoon, Taeyoon Son

Yonsei University, Department of Biomedical Engineering, Wonju, Korea

Eung-ho Choi

Yonsei University, Department of Dermatology, Wonju, Korea

Bernard Choi, J. Stuart Nelson

University of California, Irvine, Beckman Laser Institute, Irvine, California 92612

Byungjo Jung

Yonsei University, Department of Biomedical Engineering, Wonju, Korea and Yonsei University, Institute of Medical Engineering, Wonju, Korea

J. Biomed. Opt. 13(2), 021103 (April 30, 2008). doi:10.1117/1.2907483
History: Received September 20, 2007; Revised January 16, 2008; Accepted February 15, 2008; Published April 30, 2008
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Light scattering in biological tissues can be reduced by using optical clearing agents. Various physical methods in conjunction with agents have been studied to enhance the optical clearing efficacy of skin for diagnostic and therapeutic applications. In this study, we propose a new physical method to enhance the optical clearing potential of topically applied glycerol. A microneedle roller is used to easily create numerous transdermal microchannels prior to glycerol application. The optical clearing efficacy of skin is quantitatively evaluated with the use of a modulation transfer function target placed underneath ex vivo porcine skin samples. From cross-polarized images acquired at various time points after glycerol application, we find that samples treated with the microneedle roller resulted in an approximately two-fold increase in contrast compared to control samples 30min after glycerol application. In conclusion, our data suggest that the microneedle roller can be a good physical method to enhance transdermal delivery of optical clearing agents, and hence their optical clearing potential over large regions of skin.

Figures in this Article
© 2008 Society of Photo-Optical Instrumentation Engineers

Topics

Skin

Citation

Jinhee Yoon ; Taeyoon Son ; Eung-ho Choi ; Bernard Choi ; J. Stuart Nelson, et al.
"Enhancement of optical skin clearing efficacy using a microneedle roller", J. Biomed. Opt. 13(2), 021103 (April 30, 2008). ; http://dx.doi.org/10.1117/1.2907483


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