Research Papers

Curved array photoacoustic tomographic system for small animal imaging

[+] Author Affiliations
John Gamelin, Andres Aguirre, Anastasios Maurudis, Fei Huang, Diego Castillo

University of Connecticut, Department of Electrical Engineering, Storrs, Connecticut 06269

Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, St. Louis, Missouri 63130

Quing Zhu

University of Connecticut, Department of Electrical Engineering, Storrs, Connecticut 06269

J. Biomed. Opt. 13(2), 024007 (April 17, 2008). doi:10.1117/1.2907157
History: Received June 19, 2007; Revised September 06, 2007; Accepted November 06, 2007; Published April 17, 2008
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We present systematic characterization of a photoacoustic imaging system optimized for rapid, high-resolution tomographic imaging of small animals. The system is based on a 128-element ultrasonic transducer array with a 5-MHz center frequency and 80% bandwidth shaped to a quarter circle of 25mm radius. A 16-channel data-acquisition module and dedicated channel detection electronics enable capture of a 90-deg field-of-view image in less than 1s and a complete 360-deg scan using sample rotation within 15s. Measurements on cylindrical phantom targets demonstrate a resolution of better than 200μm and high-sensitivity detection of 580-μm blood tubing to depths greater than 3cm in a turbid medium with reduced scattering coefficient μs=7.8cm1. The system is used to systematically investigate the effects of target size, orientation, and geometry on tomographic imaging. As a demonstration of these effects and the system imaging capabilities, we present tomographic photoacoustic images of the brain vasculature of an ex vivo mouse with varying measurement aperture. For the first time, according to our knowledge, resolution of sub-200-μm vessels with an overlying turbid medium of greater than 2cm depth is demonstrated using only intrinsic biological contrast.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

John Gamelin ; Andres Aguirre ; Anastasios Maurudis ; Fei Huang ; Diego Castillo, et al.
"Curved array photoacoustic tomographic system for small animal imaging", J. Biomed. Opt. 13(2), 024007 (April 17, 2008). ; http://dx.doi.org/10.1117/1.2907157


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